Our actual Team

Patrick MATHIEU
Principal investigator
While studying medicine and doing a master degree in biomedical science at Université de Montreal, I researched into endothelial function and pulmonary circulation. Later I undertook at INSERM in Nantes research into molecular immunology. Back to the Institut de Cardiologie et de Pneumologie de Québec, I started my own lab with the objective to study the pathobiology of cardiovascular diseases including heart valve and vascular disorders. I consider myself privileged to lead this research group as its members include highly talented people and their dedication to research as well as their enthusiasm are driving forces of the lab. I believe research to be one of the most rewarding human activity with the endeavor to discover and develop novel therapies. In order to discover pathways involved in disorders, we rely on mapping of genetic data, network analyses, causal inference, functional genomics and control of gene expression, which constitute major topics in the lab. 
Anne RUFIANGE
Research lab manager​
It was in my 4th year of high school that I was first fascinated by DNA ; how could only four nucleic bases give all this biodiversity on our planet? I had found my field of study! A bachelor's degree in microbiology later, followed by two years of master's studies in cellular and molecular biology, I was hired as a research lab manager to set up a molecular biology laboratory at the Cancer Research Centre of Laval University, where I worked for 15 years to understand the dynamics of chromatin associated with transcription. As attested by my second bachelor's degree in Health and physical education, in addition to my courses in epidemiology and cardiovascular diseases, I wanted to combine my second passion with the first one, so I joined Dr. Patrick Mathieu's team at the Institut universitaire de cardiologie et de pneumologie de Québec (IUCPQ) research centre to better understand the genetic and molecular mechanisms involved in the development and progression of cardiovascular diseases.
As a research lab manager, In addition to working on​ the primary culture of different cell types of the human cardiac system, the development of different molecular biology techniques, including some to assay the 3D genome organization, I supervise graduate students and take care of all the management required for the proper functioning of a research team.
Hippolyte MINVIELLE MONCLA​
​PhD student
Originally from Toulouse (France), I studied at University Paul Sabatier (Toulouse III) where I received a Bachelor’s degree in cellular biology and physiology as well as a Master’s degree in physiopathology of the digestive system. I had the opportunity to work at the CBI (Center of Integrative Biology) in Toulouse. My first internship, supervised by Dr Magali Suzanne (RD), pertained to proliferation control and morphogenesis in imaginal discs during development from pupa to imago in fruit flies. My second internship was supervised by Dr Michele Crozatier (RD) and was centred on Hematopoietic and cellular response against parasitism. My third internship was supervised by Dr Arnaud Besson (RD) and Dr Justine Creff (PhD) at the Cell cycle and cancer; genome dynamics laboratory which was about intestinal cancer development and the relevance of a cyclin kinase inhibitor, p57, in the development of tumours.
During my studies, I had the opportunity to work on a large array of concepts and discuss the future of research in biology and physiopathology.  I rapidly discovered that bioinformatic tools were becoming a necessity to scientific research.
I moved to Quebec in September 2021 to join Patrick Mathieu’s team at the IUCPQ where we aim to study the impact of genomic alteration on cardiovascular diseases, using novel approaches in genomic and bioinformatic, in hope of furthering the understanding of underlying mechanisms of those diseases and help develop or adapt therapies.
Mewen BRIEND
​PhD student
I studied biology in France, where I completed a bachelor’s degree in molecular and cell biology in the University of Bretagne Sud (Vannes) as well as a master’s degree in molecular and cell biology in the University of Rennes 1 (Rennes). During my studies, I had the opportunity to work in two public laboratories in Rennes. First I did a 2-month internship in IGDR (UMR 6290 CNRS - UR1), where I studied VHL protein interactions in cell polarity in kidney cancer with Dr Franck CHESNEL. Then I did a 5-month internship in IRSET (UMR 1085 INSERM – UR1), where I studied estrogen receptor alpha during cell cycle with Dr Gilles FLOURIOT. I joined Dr Patrick Mathieu’s team in January 2022 to work in functional genomics and to develop my bio-informatics skills.
During my PhD we aim to study genetic architecture and genetic variation impact in cardiovascular diseases. This project is important to me for its use of powerful biological and bio-informatical tools to better understand diseases that impact a growing part of the population, and further the development of new therapies.​​
Valentine DUCLOS
​PhD student
Originally from Bayonne (France), I studied biology and neurosciences at the University of Strasbourg. During my studies I had the opportunity to discover a lot about fundamental biology as well as applied techniques for laboratory work. During my cursus, I completed two internships in a research team working on amyotrophic lateral sclerosis (Inserm U1118) that allowed me to familiarize myself with numerous molecular and cellular biology techniques as well as cells culture. I joined the Dr Mathieu’s team in January 2023 for my PhD, with the objective of learning more about genomics and bio-informatics techniques. 
In this PhD, I am able to increase my knowledge of molecular and cellular techniques by working on the functional roles of proteins playing a major role in CAVD. At the same time, my work in the lab offers me the opportunity to discover the far-reaching world of bio-informatics.​​
Summer Laboratory Internships
Samuel MATHIEU
Graduate research assistant; Mathematics​

Alumni

Regular Laboratory Staff
Déborah Argaud
Research lab manager​

Marie-Chloé Boulanger
Research lab manager​

Students
Arnaud Chignon
​PhD student

​Déborah Argaud
​PhD student
Valentin Bon-Baret
​PhD student
Zhonglin Li
​Bio informatic scientist
Mickael Rosa
Post-doctoral fellow
Ghada Mkannez
Post-doctoral fellow

Mohamed J. Nsaibia
​PhD student
​
Fayez Hadji
​PhD student

​Rihab Bouchareb 
Post-doctoral fellow

Diala El Husseini 
​PhD student
​
Nancy Côté
​​PhD student
Summer Laboratory Internships
Samuel Mathieu
Undergraduate research assistant; Mathematics​
Mame Sokhna Sylla
​Undergraduate research assistant; Bio informatic
Sasha-William Ménard-Mérette
​Undergraduate research assistant; Bio informatic