PUBLICATIONS
PUBLICATIONS
Research articles
2024
Combination of Waist Circumference and Circulating Levels of IGFBP-2 as a Simple Screening Tool for Early Detection of Metabolic Dysfunction-Associated Steatotic Liver Disease.
Rauzier C, Chartrand DJ, Alméras N, Lemieux I, Larose E, Mathieu P, Pibarot P, Lamarche B, Rhéaume C, Poirier P, Després JP, Picard F.
Diabetes Metab Syndr Obes. 2024 Sep 5;17:3335-3341. doi: 10.2147/DMSO.S466051.eCollection 2024.
PMID: 39252871
Lipoprotein(a) and Calcific Aortic Valve Stenosis Progression: A Systematic Review and Meta-Analysis.
Arsenault BJ, Loganath K, Girard A, Botezatu S, Zheng KH, Tzolos E, Abdoun K, Tastet L, Capoulade R, Côté N, Craig N, Chan KL, Tam JW, Teo KK, Couture C, Clavel MA, Mathieu P, Thériault S, Stroes ESG, Newby DE, Tsimikas S, Pibarot P, Dweck MR.
JAMA Cardiol. 2024 Sep 1;9(9):835-842. doi: 10.1001/jamacardio.2024.1882.
PMID: 39018080
Polygenic inheritance and its interplay with smoking history in predicting lung cancer diagnosis: a French-Canadian case-control cohort.
Boumtje V, Manikpurage HD, Li Z, Gaudreault N, Armero VS, Boudreau DK, Renaut S, Henry C, Racine C, Eslami A, Bougeard S, Vigneau E, Morissette M, Arsenault BJ, Labbé C, Laliberté AS, Martel S, Maltais F, Couture C, Desmeules P, Mathieu P, Thériault S, Joubert P, Bossé Y.
EBioMedicine. 2024 Aug;106:105234. doi: 10.1016/j.ebiom.2024.105234. Epub 2024 Jul 5.
PMID: 38970920
Genetic assessment of efficacy and safety profiles of coagulation cascade proteins identifies Factors II and XI as actionable anticoagulant targets.
Gagnon E, Girard A, Bourgault J, Abner E, Gill D, Thériault S, Vohl MC, Tchernof A, Esko T, Mathieu P, Arsenault BJ.
Eur Heart J Open. 2024 May 27;4(3):oeae043. doi: 10.1093/ehjopen/oeae043. eCollection 2024 May.
PMID: 38933427
Mendelian randomization reveals interactions of the blood proteome and immunome in mitral valve prolapse.
Minvielle Moncla LH, Briend M, Sokhna Sylla M, Mathieu S, Rufiange A, Bossé Y, Mathieu P.
Commun Med (Lond). 2024 Jun 6;4(1):108. doi: 10.1038/s43856-024-00530-x.
PMID: 38844506
Single-cell and single-nucleus RNA-sequencing from paired normal-adenocarcinoma lung samples provide both common and discordant biological insights.
Renaut S, Armero VS, Boudreau DK, Gaudreault N, Desmeules P, Thériault S, Mathieu P, Joubert P, Bossé Y.
PLoS Genet. 2024 May 30;20(5):e1011301. doi: 10.1371/journal.pgen.1011301. Online ahead of print.
PMID: 38814983
Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulation.
Thériault S, Li Z, Abner E, Luan J, Manikpurage HD, Houessou U, Zamani P, Briend M; Estonian Biobank Research Team; Boudreau DK, Gaudreault N, Frenette L, Argaud D, Dahmene M, Dagenais F, Clavel MA, Pibarot P, Arsenault BJ, Boekholdt SM, Wareham NJ, Esko T, Mathieu P, Bossé Y.
Nat Commun. 2024 Mar 18;15(1):2407. doi: 10.1038/s41467-024-46639-4.
PMID: 38494474
Genetic inhibition of angiopoietin-like protein-3, lipids, and cardiometabolic risk.
Gobeil É, Bourgault J, Mitchell PL, Houessou U, Gagnon E, Girard A, Paulin A, Manikpurage HD, Côté V, Couture C, Marceau S, Bossé Y, Thériault S, Mathieu P, Vohl MC, Tchernof A, Arsenault BJ.
Eur Heart J. 2024 Mar 1;45(9):707-721. doi: 10.1093/eurheartj/ehad845.
PMID: 38243829
2023
Contribution of Lipoprotein(a) to Polygenic Risk Prediction of Coronary Artery Disease: A Prospective UK Biobank Analysis.
Manikpurage HD, Paulin A, Girard A, Eslami A, Mathieu P, Thériault S, Arsenault BJ.
Circ Genom Precis Med. 2023 Oct;16(5):470-477. doi: 10.1161/CIRCGEN.123.004137. Epub 2023 Sep 27.
PMID: 37753708
Plasma IGFBP-2 levels reveal heterogeneity in hepatic fat content in adults with excess visceral adiposity.
Rauzier C, Chartrand DJ, Alméras N, Lemieux I, Larose E, Mathieu P, Pibarot P, Lamarche B, Rhéaume C, Poirier P, Després JP, Picard F.
Front Endocrinol (Lausanne). 2023 Oct 4;14:1222101. doi: 10.3389/fendo.2023.1222101. eCollection 2023.
PMID: 37854178
Calcific aortic valve disease: mechanisms, prevention and treatment. (REVIEW)
Moncla LM, Briend M, Bossé Y, Mathieu P.
Nat Rev Cardiol. 2023 Aug;20(8):546-559. doi: 10.1038/s41569-023-00845-7. Epub 2023 Feb 24.
PMID: 36829083
Association Between Remnant Cholesterol and Progression of Bioprosthetic Valve Degeneration.
Li Z, Zhang B, Salaun E, Côté N, Mahjoub H, Mathieu P, Dahou A, Zenses AS, Xu Y, Pibarot P, Wu Y, Clavel MA.
Eur Heart J Cardiovasc Imaging. 2023 Jul 6:jead159. doi: 10.1093/ehjci/jead159. Online ahead of print.
PMID: 37409985
Associations of insulin-like growth factor binding protein-2 (IGFBP-2) with metabolic profile and hepatic fat deposition in asymptomatic men and women.
Rauzier C, Chartrand DJ, Alméras N, Lemieux I, Larose E, Mathieu P, Pibarot P, Lamarche B, Rhéaume C, Poirier P, Després JP, Picard F.
Am J Physiol Endocrinol Metab. 2023 Jul 1;325(1):E99-E105. doi: 10.1152/ajpendo.00108.2023. Epub 2023 Jun 7.
PMID: 37285597
The journey towards identification of actionable molecular pathways in calcific aortic valve stenosis. (Editorial)
Thériault S, Mathieu P, Bossé Y.
Eur Heart J. 2023 Jun 1;44(21):1940-1942. doi: 10.1093/eurheartj/ehad134
PMID: 37042229
Proteome-Wide Mendelian Randomization Identifies Causal Links Between Blood Proteins and Acute Pancreatitis.
Bourgault J, Abner E, Manikpurage HD, Pujol-Gualdo N, Laisk T; Estonian Biobank Research Team; Gobeil É, Gagnon E, Girard A, Mitchell PL, Thériault S, Esko T, Mathieu P, Arsenault BJ.
Gastroenterology. 2023 May;164(6):953-965.e3. doi: 10.1053/j.gastro.2023.01.028. Epub 2023 Feb 1.
PMID: 36736436
Connectome and regulatory hubs of CAGE highly active enhancers.
Briend M, Rufiange A, Moncla LM, Mathieu S, Bossé Y, Mathieu P.
Sci Rep. 2023 Apr 5;13(1):5594. doi: 10.1038/s41598-023-32669-3.
PMID: 37019979
Impact of C-reactive protein levels on lipoprotein(a)-associated aortic stenosis incidence and progression.
Girard A, Gaillard E, Puri R, Capoulade R, Chan KL, Paulin A, Manikpurage HD, Dumesnil J, Tam JW, Teo KK, Couture C, Wareham NJ, Clavel MA, Stroes ESG, Mathieu P, Thériault S, Tsimikas S, Pibarot P, Boekholdt SM, Arsenault BJ.
Eur Heart J Open. 2023 Mar 30;3(2):oead032. doi: 10.1093/ehjopen/oead032. eCollection 2023 Mar.
PMID: 37077580
Genetic control of body weight by the human brain proteome.
Gagnon E, Girard A, Gobeil É, Bourgault J, Couture C, Mitchell PL, Bouchard C, Tremblay A, Mathieu P, Michaud A, Pérusse L, Arsenault BJ.
iScience. 2023 Mar 11;26(4):106376. doi: 10.1016/j.isci.2023.106376. eCollection 2023 Apr 21.
PMID: 37013190
Impact of the gut microbiota and associated metabolites on cardiometabolic traits, chronic diseases and human longevity: a Mendelian randomization study.
Gagnon E, Mitchell PL, Manikpurage HD, Abner E, Taba N, Esko T, Ghodsian N, Thériault S, Mathieu P, Arsenault BJ.
J Transl Med. 2023 Jan 30;21(1):60. doi: 10.1186/s12967-022-03799-5.
PMID: 36717893
2022
Angiopoietin-like 2 is essential to aortic valve development in mice.
Labbé P, Munoz Goyette V, Thorin-Trescases N, Villeneuve L, Desanlis I, Delwarde C, Shi YF, Martel C, Yu C, Alikashani A, Mamarbachi M, Lesage F, Mathieu S, Tardif JC, Mathieu P, Kmita M, Thorin É.
Commun Biol. 2022 Nov 21;5(1):1277. doi: 10.1038/s42003-022-04243-6.
PMID: 36414704
Genetic association and Mendelian randomization for hypothyroidism highlight immune molecular mechanisms.
Mathieu S, Briend M, Abner E, Couture C, Li Z, Bossé Y, Thériault S, Esko T, Arsenault BJ, Mathieu P.
iScience. 2022 Aug 20;25(9):104992. doi: 10.1016/j.isci.2022.104992. eCollection 2022 Sep 16.
PMID: 36093044
Mendelian randomization of circulating proteome identifies actionable targets in heart failure.
Moncla LM, Mathieu S, Sylla MS, Bossé Y, Thériault S, Arsenault BJ, Mathieu P.
BMC Genomics. 2022 Aug 13;23(1):588. doi: 10.1186/s12864-022-08811-2.
PMID: 35964012
Mendelian Randomization Analysis Identifies Blood Tyrosine Levels as a Biomarker of Non-Alcoholic Fatty Liver Disease.
Gobeil É, Maltais-Payette I, Taba N, Brière F, Ghodsian N, Abner E, Bourgault J, Gagnon E, Manikpurage HD, Couture C, Mitchell PL, Mathieu P, Julien F, Corbeil J, Vohl MC, Thériault S, Esko T, Tchernof A, Arsenault BJ.
Metabolites. 2022 May 13;12(5):440. doi: 10.3390/metabo12050440.
PMID: 35629944
Enhancer promoter interactome and Mendelian randomization identify network of druggable vascular genes in coronary artery disease.
Chignon A, Mathieu S, Rufiange A, Argaud D, Voisine P, Bossé Y, Arsenault BJ, Thériault S, Mathieu P.
Hum Genomics. 2022 Mar 4;16(1):8. doi: 10.1186/s40246-022-00381-4.
PMID: 35246263
Genome-wide chromatin contacts of super-enhancer-associated lncRNA identify LINC01013 as a regulator of fibrosis in the aortic valve.
Chignon A, Argaud D, Boulanger MC, Mkannez G, Bon-Baret V, Li Z, Thériault S, Bossé Y, Mathieu P.
PLoS Genet. 2022 Jan 18;18(1):e1010010. doi: 10.1371/journal.pgen.1010010. eCollection 2022 Jan.
PMID: 35041643
2021
Polygenic Risk Score for Coronary Artery Disease Improves the Prediction of Early-Onset Myocardial Infarction and Mortality in Men.
Manikpurage HD, Eslami A, Perrot N, Li Z, Couture C, Mathieu P, Bossé Y, Arsenault BJ, Thériault S.
Circ Genom Precis Med. 2021 Dec;14(6):e003452. doi: 10.1161/CIRCGEN.121.003452. Epub 2021 Oct 21.
PMID: 34670400
Electronic health record-based genome-wide meta-analysis provides insights on the genetic architecture of non-alcoholic fatty liver disease.
Ghodsian N, Abner E, Emdin CA, Gobeil É, Taba N, Haas ME, Perrot N, Manikpurage HD, Gagnon É, Bourgault J, St-Amand A, Couture C, Mitchell PL, Bossé Y, Mathieu P, Vohl MC, Tchernof A, Thériault S, Khera AV, Esko T, Arsenault BJ.
Cell Rep Med. 2021 Nov 3;2(11):100437. doi: 10.1016/j.xcrm.2021.100437. eCollection 2021 Nov 16.
PMID: 34841290
A trans-omic Mendelian randomization study of parental lifespan uncovers novel aging biology and therapeutic candidates for chronic diseases.
Perrot N, Pelletier W, Bourgault J, Couture C, Li Z, Mitchell PL, Ghodsian N, Bossé Y, Thériault S, Mathieu P, Arsenault BJ.
Aging Cell. 2021 Nov;20(11):e13497. doi: 10.1111/acel.13497. Epub 2021 Oct 27.
PMID: 34704651
A Role for Heme and Iron in Calcific Aortic Valve Disease? (Editorial)
Chignon A, Mathieu P.
Can J Cardiol. 2021 Sep;37(9):1310-1311. doi: 10.1016/j.cjca.2021.06.007. Epub 2021 Jun 18.
PMID: 34147622
Lipoprotein Proteomics and Aortic Valve Transcriptomics Identify Biological Pathways Linking Lipoprotein(a) Levels to Aortic Stenosis.
Bourgeois R, Bourgault J, Despres AA, Perrot N, Guertin J, Girard A, Mitchell PL, Gotti C, Bourassa S, Scipione CA, Gaudreault N, Boffa MB, Koschinsky ML, Pibarot P, Droit A, Thériault S, Mathieu P, Bossé Y, Arsenault BJ.
Metabolites. 2021 Jul 16;11(7):459. doi: 10.3390/metabo11070459.
PMID: 34357353
Sex-Specific Associations of Genetically Predicted Circulating Lp(a) (Lipoprotein(a)) and Hepatic LPA Gene Expression Levels With Cardiovascular Outcomes: Mendelian Randomization and Observational Analyses.
Guertin J, Kaiser Y, Manikpurage H, Perrot N, Bourgeois R, Couture C, Wareham NJ, Bossé Y, Pibarot P, Stroes ESG, Mathieu P, Clavel MA, Thériault S, Boekholdt SM, Arsenault BJ.
Circ Genom Precis Med. 2021 Aug;14(4):e003271. doi: 10.1161/CIRCGEN.120.003271. Epub 2021 Jul 19.
PMID: 34279996
Lipoprotein Proteomics and Aortic Valve Transcriptomics Identify Biological Pathways Linking Lipoprotein(a) Levels to Aortic Stenosis.
Bourgeois R, Bourgault J, Despres AA, Perrot N, Guertin J, Girard A, Mitchell PL, Gotti C, Bourassa S, Scipione CA, Gaudreault N, Boffa MB, Koschinsky ML, Pibarot P, Droit A, Thériault S, Mathieu P, Bossé Y, Arsenault BJ.
Metabolites. 2021 Jul 16;11(7):459. doi: 10.3390/metabo11070459.
PMID: 34357353
Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank.
Valette K, Li Z, Bon-Baret V, Chignon A, Bérubé JC, Eslami A, Lamothe J, Gaudreault N, Joubert P, Obeidat M, van den Berge M, Timens W, Sin DD, Nickle DC, Hao K, Labbé C, Godbout K, Côté A, Laviolette M, Boulet LP, Mathieu P, Thériault S, Bossé Y.
Commun Biol. 2021 Jun 8;4(1):700. doi: 10.1038/s42003-021-02227-6.
PMID: 34103634
Fish oil replacement prevents, while docosahexaenoic acid-derived protectin DX mitigates end-stage-renal-disease in atherosclerotic diabetic mice.
Perazza LR, Mitchell PL, Lizotte F, Jensen BAH, St-Pierre P, Trottier J, Barbier O, Mathieu P, Geraldes PM, Marette A.
FASEB J. 2021 May;35(5):e21559. doi: 10.1096/fj.202100073R.
PMID: 33835594
A Comparative Analysis of the Lipoprotein(a) and Low-Density Lipoprotein Proteomic Profiles Combining Mass Spectrometry and Mendelian Randomization.
Bourgeois R, Girard A, Perrot N, Guertin J, Mitchell PL, Couture C, Gotti C, Bourassa S, Poggio P, Mass E, Capoulade R, Scipione CA, Després AA, Couture P, Droit A, Pibarot P, Boffa MB, Thériault S, Koschinsky ML, Mathieu P, Arsenault BJ.
CJC Open. 2020 Dec 3;3(4):450-459. doi: 10.1016/j.cjco.2020.11.019. eCollection 2021 Apr.
PMID: 34027348
System Genetics Including Causal Inference Identify Immune Targets for Coronary Artery Disease and the Lifespan.
Bon-Baret V, Chignon A, Boulanger MC, Li Z, Argaud D, Arsenault BJ, Thériault S, Bossé Y, Mathieu P.
Circ Genom Precis Med. 2021 Apr;14(2):e003196. doi: 10.1161/CIRCGEN.120.003196. Epub 2021 Feb 24.
PMID: 33625251
Enhancer-associated aortic valve stenosis risk locus 1p21.2 alters NFATC2 binding site and promotes fibrogenesis.
Chignon A, Rosa M, Boulanger MC, Argaud D, Devillers R, Bon-Baret V, Mkannez G, Li Z, Rufiange A, Gaudreault N, Gosselin D, Thériault S, Bossé Y, Mathieu P.
iScience. 2021 Feb 27;24(3):102241. doi: 10.1016/j.isci.2021.102241. eCollection 2021 Mar 19.
PMID: 33748722
Oxyphospholipids in Cardiovascular Calcification. (REVIEW)
Chignon A, Bon-Baret V, Boulanger MC, Bossé Y, Mathieu P.
Arterioscler Thromb Vasc Biol. 2021 Jan;41(1):11-19. doi: 10.1161/ATVBAHA.120.313790. Epub 2020 Nov 24.
PMID: 33232199
2020
Association of Bioprosthetic Aortic Valve Leaflet Calcification on Hemodynamic and Clinical Outcomes.
Zhang B, Salaun E, Côté N, Wu Y, Mahjoub H, Mathieu P, Dahou A, Zenses AS, Clisson M, Pibarot P, Clavel MA.
J Am Coll Cardiol. 2020 Oct 13;76(15):1737-1748. doi: 10.1016/j.jacc.2020.08.034.
PMID: 33032735
Acute and Chronic Impact of Biliopancreatic Diversion with Duodenal Switch Surgery on Plasma Lipoprotein(a) Levels in Patients with Severe Obesity.
Després AA, Piché ME, Auclair A, Biertho L, Marceau S, Hould FS, Biron S, Lebel S, Lescelleur O, Julien F, Martin J, Tchernof A, Mathieu P, Poirier P, Arsenault BJ.Obes Surg. 2020 Oct;30(10):3714-3720. doi: 10.1007/s11695-020-04450-2. Epub 2020 Jul 14.
PMID: 32666413
Interaction of Autotaxin With Lipoprotein(a) in Patients With Calcific Aortic Valve Stenosis.
Bourgeois R, Devillers R, Perrot N, Després AA, Boulanger MC, Mitchell PL, Guertin J, Couture P, Boffa MB, Scipione CA, Pibarot P, Koschinsky ML, Mathieu P, Arsenault BJ.
JACC Basic Transl Sci. 2020 Aug 26;5(9):888-897. doi: 10.1016/j.jacbts.2020.06.012. eCollection 2020 Sep.
PMID: 33015412
Visceral adiposity and liver fat as mediators of the association between cardiorespiratory fitness and plasma glucose-insulin homeostasis.
Chartrand DJ, Larose E, Poirier P, Mathieu P, Alméras N, Pibarot P, Lamarche B, Rhéaume C, Després JP.Am J Physiol Endocrinol Metab. 2020 Sep 1;319(3):E548-E556. doi: 10.1152/ajpendo.00251.2020. Epub 2020 Jul 27.
PMID: 32715747
Lipoprotein-associated phospholipase A2 activity, genetics and calcific aortic valve stenosis in humans.
Perrot N, Thériault S, Rigade S, Chen HY, Dina C, Martinsson A, Boekholdt SM, Capoulade R, Le Tourneau T, Messika-Zeitoun D, Engert JC, Wareham NJ, Clavel MA, Pibarot P, Smith JG, Schott JJ, Mathieu P, Bossé Y, Thanassoulis G, Arsenault BJ.
Heart. 2020 Sep;106(18):1407-1412. doi: 10.1136/heartjnl-2020-316722. Epub 2020 Jul 7.
PMID: 32636298
Phenome-wide analyses establish a specific association between aortic valve PALMD expression and calcific aortic valve stenosis.
Li Z, Gaudreault N, Arsenault BJ, Mathieu P, Bossé Y, Thériault S.
Commun Biol. 2020 Aug 28;3(1):477. doi: 10.1038/s42003-020-01210-x.
PMID: 32859967
Warning AlarmIn Diabetes Mellitus: A Balancing Act Between Inflammation and Redox Signaling in Vascular Mineralization.
Bon-Baret V, Chignon A, Boulanger MC, Mathieu P.
Arterioscler Thromb Vasc Biol. 2020 Aug;40(8):1804-1807. doi: 10.1161/ATVBAHA.120.314733. Epub 2020 Jul 22.
PMID: 32697681
Genetic and In Vitro Inhibition of PCSK9 and Calcific Aortic Valve Stenosis.
Perrot N, Valerio V, Moschetta D, Boekholdt SM, Dina C, Chen HY, Abner E, Martinsson A, Manikpurage HD, Rigade S, Capoulade R, Mass E, Clavel MA, Le Tourneau T, Messika-Zeitoun D, Wareham NJ, Engert JC, Polvani G, Pibarot P, Esko T, Smith JG, Mathieu P, Thanassoulis G, Schott JJ, Bossé Y, Camera M, Thériault S, Poggio P, Arsenault BJ.
JACC Basic Transl Sci. 2020 Jul 1;5(7):649-661. doi: 10.1016/j.jacbts.2020.05.004. eCollection 2020 Jul.
PMID: 32760854
Dietary sucrose induces metabolic inflammation and atherosclerotic cardiovascular diseases more than dietary fat in LDLr-/-ApoB100/100 mice.
Perazza LR, Mitchell PL, Jensen BAH, Daniel N, Boyer M, Varin TV, Bouchareb R, Nachbar RT, Bouchard M, Blais M, Gagné A, Joubert P, Sweeney G, Roy D, Arsenault BJ, Mathieu P, Marette A.
Atherosclerosis. 2020 Jul;304:9-21. doi: 10.1016/j.atherosclerosis.2020.05.002. Epub 2020 May 24.
PMID: 32563005
Association of FADS1/2 Locus Variants and Polyunsaturated Fatty Acids With Aortic Stenosis.
Chen HY, Cairns BJ, Small AM, Burr HA, Ambikkumar A, Martinsson A, Thériault S, Munter HM, Steffen B, Zhang R, Levinson RT, Shaffer CM, Rong J, Sonestedt E, Dufresne L, Ljungberg J, Näslund U, Johansson B, Ranatunga DK, Whitmer RA, Budoff MJ, Nguyen A, Vasan RS, Larson MG, Harris WS, Damrauer SM, Stark KD, Boekholdt SM, Wareham NJ, Pibarot P, Arsenault BJ, Mathieu P, Gudnason V, O'Donnell CJ, Rotter JI, Tsai MY, Post WS, Clarke R, Söderberg S, Bossé Y, Wells QS, Smith JG, Rader DJ, Lathrop M, Engert JC, Thanassoulis G.
JAMA Cardiol. 2020 Mar 18:e200246. doi: 10.1001/jamacardio.2020.0246. Online ahead of print.
PMID: 32186652
Age, Sex, and Valve Phenotype Differences in Fibro-Calcific Remodeling of Calcified Aortic Valve.
Voisine M, Hervault M, Shen M, Boilard AJ, Filion B, Rosa M, Bossé Y, Mathieu P, Côté N, Clavel MA.
J Am Heart Assoc. 2020 May 8:e015610. doi: 10.1161/JAHA.119.015610. Online ahead of print.
MID: 32384012
Single-cell expression and Mendelian randomization analyses identify blood genes associated with lifespan and chronic diseases.
Chignon A, Bon-Baret V, Boulanger MC, Li Z, Argaud D, Bossé Y, Thériault S, Arsenault BJ, Mathieu P.
Commun Biol. 2020 May 1;3(1):206. doi: 10.1038/s42003-020-0937-x
PMID: 32358504
ApoCIII-Lp(a) complexes in conjunction with Lp(a)-OxPL predict rapid progression of aortic stenosis.
Capoulade R, Torzewski M, Mayr M, Chan KL, Mathieu P, Bossé Y, Dumesnil JG, Tam J, Teo KK, Burnap SA, Schmid J, Gobel N, Franke UFW, Sanchez A, Witztum JL, Yang X, Yeang C, Arsenault B, Després JP, Pibarot P, Tsimikas S.
Heart. 2020 May;106(10):738-745. doi: 10.1136/heartjnl-2019-315840. Epub 2020 Feb 13.
PMID: 32054669
Association of Long-term Exposure to Elevated Lipoprotein(a) Levels With Parental Life Span, Chronic Disease-Free Survival, and Mortality Risk: A Mendelian Randomization Analysis.
Arsenault BJ, Pelletier W, Kaiser Y, Perrot N, Couture C, Khaw KT, Wareham NJ, Bossé Y, Pibarot P, Stroes ESG, Mathieu P, Thériault S, Boekholdt SM.
JAMA Netw Open. 2020 Feb 5;3(2):e200129. doi: 10.1001/jamanetworkopen.2020.0129.
PMID: 32108890
Attenuated Mitral Leaflet Enlargement Contributes to Functional Mitral Regurgitation After Myocardial Infarction.
Marsit O, Clavel MA, Côté-Laroche C, Hadjadj S, Bouchard MA, Handschumacher MD, Clisson M, Drolet MC, Boulanger MC, Kim DH, Guerrero JL, Bartko PE, Couet J, Arsenault M, Mathieu P, Pibarot P, Aïkawa E, Bischoff J, Levine RA, Beaudoin J.
J Am Coll Cardiol. 2020 Feb 4;75(4):395-405. doi: 10.1016/j.jacc.2019.11.039.
PMID: 32000951
2019
Genetic Association Analyses Highlight IL6, ALPL, and NAV1 As 3 New Susceptibility Genes Underlying Calcific Aortic Valve Stenosis.
Thériault S, Dina C, Messika-Zeitoun D, Le Scouarnec S, Capoulade R, Gaudreault N, Rigade S, Li Z, Simonet F, Lamontagne M, Clavel MA, Arsenault BJ, Boureau AS, Lecointe S, Baron E, Bonnaud S, Karakachoff M, Charpentier E, Fellah I, Roussel JC, Philippe Verhoye J, Baufreton C, Probst V, Roussel R; D.E.S.I.R. Study Group, Redon R, Dagenais F, Pibarot P, Mathieu P, Le Tourneau T, Bossé Y, Schott JJ.
Circ Genom Precis Med. 2019 Oct;12(10):e002617. doi: 10.1161/CIRCGEN.119.002617. Epub 2019 Oct 15.
PMID: 32141789
A Mendelian randomization study of IL6 signaling in cardiovascular diseases, immune-related disorders and longevity.
Rosa M, Chignon A, Li Z, Boulanger MC, Arsenault BJ, Bossé Y, Thériault S, Mathieu P.
NPJ Genom Med. 2019 Sep 20;4:23. doi: 10.1038/s41525-019-0097-4. eCollection 2019.
PMID: 31552141
Enhancer-mediated enrichment of interacting JMJD3-DDX21 to ENPP2 locus prevents R-loop formation and promotes transcription.
Argaud D, Boulanger MC, Chignon A, Mkannez G, Mathieu P.
Nucleic Acids Res. 2019 Jun 28. pii: gkz560. doi: 10.1093/nar/gkz560. [Epub ahead of print]
PMID:31251802
Genetic Variation in LPA, Calcific Aortic Valve Stenosis in Patients Undergoing Cardiac Surgery, and Familial Risk of Aortic Valve Microcalcification.
Perrot N, Thériault S, Dina C, Chen HY, Boekholdt SM, Rigade S, Després AA, Poulin A, Capoulade R, Le Tourneau T, Messika-Zeitoun D, Trottier M, Tessier M, Guimond J, Nadeau M, Engert JC, Khaw KT, Wareham NJ, Dweck MR, Mathieu P, Pibarot P, Schott JJ, Thanassoulis G, Clavel MA, Bossé Y, Arsenault BJ.
JAMA Cardiol. 2019 Jul 1;4(7):620-627. doi: 10.1001/jamacardio.2019.1581.
PMID: 31141105
Lipoprotein(a), Oxidized Phospholipids, and Aortic Valve Microcalcification Assessed by 18F-Sodium Fluoride Positron Emission Tomography and Computed Tomography.
Després AA, Perrot N, Poulin A, Tastet L, Shen M, Chen HY, Bourgeois R, Trottier M, Tessier M, Guimond J, Nadeau M, Engert JC, Thériault S, Bossé Y, Witztum JL, Couture P, Mathieu P, Dweck MR, Tsimikas S, Thanassoulis G, Pibarot P, Clavel MA, Arsenault BJ.
CJC Open. 2019 Apr 12;1(3):131-140. doi: 10.1016/j.cjco.2019.03.004. eCollection 2019 May.
PMID: 32159096
Activated platelets promote an osteogenic programme and the progression of calcific aortic valve stenosis.
Bouchareb R, Boulanger MC, Tastet L, Mkannez G, Nsaibia MJ, Hadji F, Dahou A, Messadeq Y, Arsenault BJ, Pibarot P, Bossé Y, Marette A, Mathieu P.
Eur Heart J. 2019 May 1;40(17):1362-1373. doi: 10.1093/eurheartj/ehy696.
PMID:30395215
UCP1 expression-associated gene signatures of human epicardial adipose tissue.
Chechi K, Vijay J, Voisine P, Mathieu P, Bossé Y, Tchernof A, Grundberg E, Richard D.
JCI Insight. 2019 Apr 18;4(8):e123618. doi: 10.1172/jci.insight.123618. eCollection 2019 Apr 18.
PMID: 30996144
Benefits of 1-Year Lifestyle Modification Program on Exercise Capacity and Diastolic Function Among Coronary Artery Disease Men With and Without Type 2 Diabetes.
Piché ME, Poirier P, Marette A, Mathieu P, Lévesque V, Bibeau K, Larose É, Després JP.
Metab Syndr Relat Disord. 2019 Apr;17(3):149-159. doi: 10.1089/met.2018.0092. Epub 2019 Feb 21.
PMID: 30789304
PALMD as a novel target for calcific aortic valve stenosis (REVIEW)
Bossé Y, Mathieu P, Thériault S.
Curr Opin Cardiol. 2019 Mar;34(2):105-111. doi: 10.1097/HCO.0000000000000605.
PMID:30608251
Acute and chronic effect of bariatric surgery on circulating autotaxin levels.
Bourgeois R, Piché ME, Auclair A, Grenier-Larouche T, Mitchell PL, Poirier P, Biertho L, Marceau S, Hould FS, Biron S, Lebel S, Lescelleur O, Julien F, Martin J, Tchernof A, Mathieu P, Carpentier AC, Arsenault BJ.
Physiol Rep. 2019 Mar;7(5):e14004. doi: 10.14814/phy2.14004.
PMID: 30821134
Autotaxin and Lipoprotein Metabolism in Calcific Aortic Valve Disease. (REVIEW)
Mathieu P, Boulanger MC.
Front Cardiovasc Med. 2019 Mar 1;6:18. doi: 10.3389/fcvm.2019.00018. eCollection 2019. Review.
PMID:30881959
Combination of Waist Circumference and Circulating Levels of IGFBP-2 as a Simple Screening Tool for Early Detection of Metabolic Dysfunction-Associated Steatotic Liver Disease.
Rauzier C, Chartrand DJ, Alméras N, Lemieux I, Larose E, Mathieu P, Pibarot P, Lamarche B, Rhéaume C, Poirier P, Després JP, Picard F.
Diabetes Metab Syndr Obes. 2024 Sep 5;17:3335-3341. doi: 10.2147/DMSO.S466051.eCollection 2024.
PMID: 39252871
Lipoprotein(a) and Calcific Aortic Valve Stenosis Progression: A Systematic Review and Meta-Analysis.
Arsenault BJ, Loganath K, Girard A, Botezatu S, Zheng KH, Tzolos E, Abdoun K, Tastet L, Capoulade R, Côté N, Craig N, Chan KL, Tam JW, Teo KK, Couture C, Clavel MA, Mathieu P, Thériault S, Stroes ESG, Newby DE, Tsimikas S, Pibarot P, Dweck MR.
JAMA Cardiol. 2024 Sep 1;9(9):835-842. doi: 10.1001/jamacardio.2024.1882.
PMID: 39018080
Polygenic inheritance and its interplay with smoking history in predicting lung cancer diagnosis: a French-Canadian case-control cohort.
Boumtje V, Manikpurage HD, Li Z, Gaudreault N, Armero VS, Boudreau DK, Renaut S, Henry C, Racine C, Eslami A, Bougeard S, Vigneau E, Morissette M, Arsenault BJ, Labbé C, Laliberté AS, Martel S, Maltais F, Couture C, Desmeules P, Mathieu P, Thériault S, Joubert P, Bossé Y.
EBioMedicine. 2024 Aug;106:105234. doi: 10.1016/j.ebiom.2024.105234. Epub 2024 Jul 5.
PMID: 38970920
Genetic assessment of efficacy and safety profiles of coagulation cascade proteins identifies Factors II and XI as actionable anticoagulant targets.
Gagnon E, Girard A, Bourgault J, Abner E, Gill D, Thériault S, Vohl MC, Tchernof A, Esko T, Mathieu P, Arsenault BJ.
Eur Heart J Open. 2024 May 27;4(3):oeae043. doi: 10.1093/ehjopen/oeae043. eCollection 2024 May.
PMID: 38933427
Mendelian randomization reveals interactions of the blood proteome and immunome in mitral valve prolapse.
Minvielle Moncla LH, Briend M, Sokhna Sylla M, Mathieu S, Rufiange A, Bossé Y, Mathieu P.
Commun Med (Lond). 2024 Jun 6;4(1):108. doi: 10.1038/s43856-024-00530-x.
PMID: 38844506
Single-cell and single-nucleus RNA-sequencing from paired normal-adenocarcinoma lung samples provide both common and discordant biological insights.
Renaut S, Armero VS, Boudreau DK, Gaudreault N, Desmeules P, Thériault S, Mathieu P, Joubert P, Bossé Y.
PLoS Genet. 2024 May 30;20(5):e1011301. doi: 10.1371/journal.pgen.1011301. Online ahead of print.
PMID: 38814983
Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulation.
Thériault S, Li Z, Abner E, Luan J, Manikpurage HD, Houessou U, Zamani P, Briend M; Estonian Biobank Research Team; Boudreau DK, Gaudreault N, Frenette L, Argaud D, Dahmene M, Dagenais F, Clavel MA, Pibarot P, Arsenault BJ, Boekholdt SM, Wareham NJ, Esko T, Mathieu P, Bossé Y.
Nat Commun. 2024 Mar 18;15(1):2407. doi: 10.1038/s41467-024-46639-4.
PMID: 38494474
Genetic inhibition of angiopoietin-like protein-3, lipids, and cardiometabolic risk.
Gobeil É, Bourgault J, Mitchell PL, Houessou U, Gagnon E, Girard A, Paulin A, Manikpurage HD, Côté V, Couture C, Marceau S, Bossé Y, Thériault S, Mathieu P, Vohl MC, Tchernof A, Arsenault BJ.
Eur Heart J. 2024 Mar 1;45(9):707-721. doi: 10.1093/eurheartj/ehad845.
PMID: 38243829
2023
Contribution of Lipoprotein(a) to Polygenic Risk Prediction of Coronary Artery Disease: A Prospective UK Biobank Analysis.
Manikpurage HD, Paulin A, Girard A, Eslami A, Mathieu P, Thériault S, Arsenault BJ.
Circ Genom Precis Med. 2023 Oct;16(5):470-477. doi: 10.1161/CIRCGEN.123.004137. Epub 2023 Sep 27.
PMID: 37753708
Plasma IGFBP-2 levels reveal heterogeneity in hepatic fat content in adults with excess visceral adiposity.
Rauzier C, Chartrand DJ, Alméras N, Lemieux I, Larose E, Mathieu P, Pibarot P, Lamarche B, Rhéaume C, Poirier P, Després JP, Picard F.
Front Endocrinol (Lausanne). 2023 Oct 4;14:1222101. doi: 10.3389/fendo.2023.1222101. eCollection 2023.
PMID: 37854178
Calcific aortic valve disease: mechanisms, prevention and treatment. (REVIEW)
Moncla LM, Briend M, Bossé Y, Mathieu P.
Nat Rev Cardiol. 2023 Aug;20(8):546-559. doi: 10.1038/s41569-023-00845-7. Epub 2023 Feb 24.
PMID: 36829083
Association Between Remnant Cholesterol and Progression of Bioprosthetic Valve Degeneration.
Li Z, Zhang B, Salaun E, Côté N, Mahjoub H, Mathieu P, Dahou A, Zenses AS, Xu Y, Pibarot P, Wu Y, Clavel MA.
Eur Heart J Cardiovasc Imaging. 2023 Jul 6:jead159. doi: 10.1093/ehjci/jead159. Online ahead of print.
PMID: 37409985
Associations of insulin-like growth factor binding protein-2 (IGFBP-2) with metabolic profile and hepatic fat deposition in asymptomatic men and women.
Rauzier C, Chartrand DJ, Alméras N, Lemieux I, Larose E, Mathieu P, Pibarot P, Lamarche B, Rhéaume C, Poirier P, Després JP, Picard F.
Am J Physiol Endocrinol Metab. 2023 Jul 1;325(1):E99-E105. doi: 10.1152/ajpendo.00108.2023. Epub 2023 Jun 7.
PMID: 37285597
The journey towards identification of actionable molecular pathways in calcific aortic valve stenosis. (Editorial)
Thériault S, Mathieu P, Bossé Y.
Eur Heart J. 2023 Jun 1;44(21):1940-1942. doi: 10.1093/eurheartj/ehad134
PMID: 37042229
Proteome-Wide Mendelian Randomization Identifies Causal Links Between Blood Proteins and Acute Pancreatitis.
Bourgault J, Abner E, Manikpurage HD, Pujol-Gualdo N, Laisk T; Estonian Biobank Research Team; Gobeil É, Gagnon E, Girard A, Mitchell PL, Thériault S, Esko T, Mathieu P, Arsenault BJ.
Gastroenterology. 2023 May;164(6):953-965.e3. doi: 10.1053/j.gastro.2023.01.028. Epub 2023 Feb 1.
PMID: 36736436
Connectome and regulatory hubs of CAGE highly active enhancers.
Briend M, Rufiange A, Moncla LM, Mathieu S, Bossé Y, Mathieu P.
Sci Rep. 2023 Apr 5;13(1):5594. doi: 10.1038/s41598-023-32669-3.
PMID: 37019979
Impact of C-reactive protein levels on lipoprotein(a)-associated aortic stenosis incidence and progression.
Girard A, Gaillard E, Puri R, Capoulade R, Chan KL, Paulin A, Manikpurage HD, Dumesnil J, Tam JW, Teo KK, Couture C, Wareham NJ, Clavel MA, Stroes ESG, Mathieu P, Thériault S, Tsimikas S, Pibarot P, Boekholdt SM, Arsenault BJ.
Eur Heart J Open. 2023 Mar 30;3(2):oead032. doi: 10.1093/ehjopen/oead032. eCollection 2023 Mar.
PMID: 37077580
Genetic control of body weight by the human brain proteome.
Gagnon E, Girard A, Gobeil É, Bourgault J, Couture C, Mitchell PL, Bouchard C, Tremblay A, Mathieu P, Michaud A, Pérusse L, Arsenault BJ.
iScience. 2023 Mar 11;26(4):106376. doi: 10.1016/j.isci.2023.106376. eCollection 2023 Apr 21.
PMID: 37013190
Impact of the gut microbiota and associated metabolites on cardiometabolic traits, chronic diseases and human longevity: a Mendelian randomization study.
Gagnon E, Mitchell PL, Manikpurage HD, Abner E, Taba N, Esko T, Ghodsian N, Thériault S, Mathieu P, Arsenault BJ.
J Transl Med. 2023 Jan 30;21(1):60. doi: 10.1186/s12967-022-03799-5.
PMID: 36717893
2022
Angiopoietin-like 2 is essential to aortic valve development in mice.
Labbé P, Munoz Goyette V, Thorin-Trescases N, Villeneuve L, Desanlis I, Delwarde C, Shi YF, Martel C, Yu C, Alikashani A, Mamarbachi M, Lesage F, Mathieu S, Tardif JC, Mathieu P, Kmita M, Thorin É.
Commun Biol. 2022 Nov 21;5(1):1277. doi: 10.1038/s42003-022-04243-6.
PMID: 36414704
Genetic association and Mendelian randomization for hypothyroidism highlight immune molecular mechanisms.
Mathieu S, Briend M, Abner E, Couture C, Li Z, Bossé Y, Thériault S, Esko T, Arsenault BJ, Mathieu P.
iScience. 2022 Aug 20;25(9):104992. doi: 10.1016/j.isci.2022.104992. eCollection 2022 Sep 16.
PMID: 36093044
Mendelian randomization of circulating proteome identifies actionable targets in heart failure.
Moncla LM, Mathieu S, Sylla MS, Bossé Y, Thériault S, Arsenault BJ, Mathieu P.
BMC Genomics. 2022 Aug 13;23(1):588. doi: 10.1186/s12864-022-08811-2.
PMID: 35964012
Mendelian Randomization Analysis Identifies Blood Tyrosine Levels as a Biomarker of Non-Alcoholic Fatty Liver Disease.
Gobeil É, Maltais-Payette I, Taba N, Brière F, Ghodsian N, Abner E, Bourgault J, Gagnon E, Manikpurage HD, Couture C, Mitchell PL, Mathieu P, Julien F, Corbeil J, Vohl MC, Thériault S, Esko T, Tchernof A, Arsenault BJ.
Metabolites. 2022 May 13;12(5):440. doi: 10.3390/metabo12050440.
PMID: 35629944
Enhancer promoter interactome and Mendelian randomization identify network of druggable vascular genes in coronary artery disease.
Chignon A, Mathieu S, Rufiange A, Argaud D, Voisine P, Bossé Y, Arsenault BJ, Thériault S, Mathieu P.
Hum Genomics. 2022 Mar 4;16(1):8. doi: 10.1186/s40246-022-00381-4.
PMID: 35246263
Genome-wide chromatin contacts of super-enhancer-associated lncRNA identify LINC01013 as a regulator of fibrosis in the aortic valve.
Chignon A, Argaud D, Boulanger MC, Mkannez G, Bon-Baret V, Li Z, Thériault S, Bossé Y, Mathieu P.
PLoS Genet. 2022 Jan 18;18(1):e1010010. doi: 10.1371/journal.pgen.1010010. eCollection 2022 Jan.
PMID: 35041643
2021
Polygenic Risk Score for Coronary Artery Disease Improves the Prediction of Early-Onset Myocardial Infarction and Mortality in Men.
Manikpurage HD, Eslami A, Perrot N, Li Z, Couture C, Mathieu P, Bossé Y, Arsenault BJ, Thériault S.
Circ Genom Precis Med. 2021 Dec;14(6):e003452. doi: 10.1161/CIRCGEN.121.003452. Epub 2021 Oct 21.
PMID: 34670400
Electronic health record-based genome-wide meta-analysis provides insights on the genetic architecture of non-alcoholic fatty liver disease.
Ghodsian N, Abner E, Emdin CA, Gobeil É, Taba N, Haas ME, Perrot N, Manikpurage HD, Gagnon É, Bourgault J, St-Amand A, Couture C, Mitchell PL, Bossé Y, Mathieu P, Vohl MC, Tchernof A, Thériault S, Khera AV, Esko T, Arsenault BJ.
Cell Rep Med. 2021 Nov 3;2(11):100437. doi: 10.1016/j.xcrm.2021.100437. eCollection 2021 Nov 16.
PMID: 34841290
A trans-omic Mendelian randomization study of parental lifespan uncovers novel aging biology and therapeutic candidates for chronic diseases.
Perrot N, Pelletier W, Bourgault J, Couture C, Li Z, Mitchell PL, Ghodsian N, Bossé Y, Thériault S, Mathieu P, Arsenault BJ.
Aging Cell. 2021 Nov;20(11):e13497. doi: 10.1111/acel.13497. Epub 2021 Oct 27.
PMID: 34704651
A Role for Heme and Iron in Calcific Aortic Valve Disease? (Editorial)
Chignon A, Mathieu P.
Can J Cardiol. 2021 Sep;37(9):1310-1311. doi: 10.1016/j.cjca.2021.06.007. Epub 2021 Jun 18.
PMID: 34147622
Lipoprotein Proteomics and Aortic Valve Transcriptomics Identify Biological Pathways Linking Lipoprotein(a) Levels to Aortic Stenosis.
Bourgeois R, Bourgault J, Despres AA, Perrot N, Guertin J, Girard A, Mitchell PL, Gotti C, Bourassa S, Scipione CA, Gaudreault N, Boffa MB, Koschinsky ML, Pibarot P, Droit A, Thériault S, Mathieu P, Bossé Y, Arsenault BJ.
Metabolites. 2021 Jul 16;11(7):459. doi: 10.3390/metabo11070459.
PMID: 34357353
Sex-Specific Associations of Genetically Predicted Circulating Lp(a) (Lipoprotein(a)) and Hepatic LPA Gene Expression Levels With Cardiovascular Outcomes: Mendelian Randomization and Observational Analyses.
Guertin J, Kaiser Y, Manikpurage H, Perrot N, Bourgeois R, Couture C, Wareham NJ, Bossé Y, Pibarot P, Stroes ESG, Mathieu P, Clavel MA, Thériault S, Boekholdt SM, Arsenault BJ.
Circ Genom Precis Med. 2021 Aug;14(4):e003271. doi: 10.1161/CIRCGEN.120.003271. Epub 2021 Jul 19.
PMID: 34279996
Lipoprotein Proteomics and Aortic Valve Transcriptomics Identify Biological Pathways Linking Lipoprotein(a) Levels to Aortic Stenosis.
Bourgeois R, Bourgault J, Despres AA, Perrot N, Guertin J, Girard A, Mitchell PL, Gotti C, Bourassa S, Scipione CA, Gaudreault N, Boffa MB, Koschinsky ML, Pibarot P, Droit A, Thériault S, Mathieu P, Bossé Y, Arsenault BJ.
Metabolites. 2021 Jul 16;11(7):459. doi: 10.3390/metabo11070459.
PMID: 34357353
Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank.
Valette K, Li Z, Bon-Baret V, Chignon A, Bérubé JC, Eslami A, Lamothe J, Gaudreault N, Joubert P, Obeidat M, van den Berge M, Timens W, Sin DD, Nickle DC, Hao K, Labbé C, Godbout K, Côté A, Laviolette M, Boulet LP, Mathieu P, Thériault S, Bossé Y.
Commun Biol. 2021 Jun 8;4(1):700. doi: 10.1038/s42003-021-02227-6.
PMID: 34103634
Fish oil replacement prevents, while docosahexaenoic acid-derived protectin DX mitigates end-stage-renal-disease in atherosclerotic diabetic mice.
Perazza LR, Mitchell PL, Lizotte F, Jensen BAH, St-Pierre P, Trottier J, Barbier O, Mathieu P, Geraldes PM, Marette A.
FASEB J. 2021 May;35(5):e21559. doi: 10.1096/fj.202100073R.
PMID: 33835594
A Comparative Analysis of the Lipoprotein(a) and Low-Density Lipoprotein Proteomic Profiles Combining Mass Spectrometry and Mendelian Randomization.
Bourgeois R, Girard A, Perrot N, Guertin J, Mitchell PL, Couture C, Gotti C, Bourassa S, Poggio P, Mass E, Capoulade R, Scipione CA, Després AA, Couture P, Droit A, Pibarot P, Boffa MB, Thériault S, Koschinsky ML, Mathieu P, Arsenault BJ.
CJC Open. 2020 Dec 3;3(4):450-459. doi: 10.1016/j.cjco.2020.11.019. eCollection 2021 Apr.
PMID: 34027348
System Genetics Including Causal Inference Identify Immune Targets for Coronary Artery Disease and the Lifespan.
Bon-Baret V, Chignon A, Boulanger MC, Li Z, Argaud D, Arsenault BJ, Thériault S, Bossé Y, Mathieu P.
Circ Genom Precis Med. 2021 Apr;14(2):e003196. doi: 10.1161/CIRCGEN.120.003196. Epub 2021 Feb 24.
PMID: 33625251
Enhancer-associated aortic valve stenosis risk locus 1p21.2 alters NFATC2 binding site and promotes fibrogenesis.
Chignon A, Rosa M, Boulanger MC, Argaud D, Devillers R, Bon-Baret V, Mkannez G, Li Z, Rufiange A, Gaudreault N, Gosselin D, Thériault S, Bossé Y, Mathieu P.
iScience. 2021 Feb 27;24(3):102241. doi: 10.1016/j.isci.2021.102241. eCollection 2021 Mar 19.
PMID: 33748722
Oxyphospholipids in Cardiovascular Calcification. (REVIEW)
Chignon A, Bon-Baret V, Boulanger MC, Bossé Y, Mathieu P.
Arterioscler Thromb Vasc Biol. 2021 Jan;41(1):11-19. doi: 10.1161/ATVBAHA.120.313790. Epub 2020 Nov 24.
PMID: 33232199
2020
Association of Bioprosthetic Aortic Valve Leaflet Calcification on Hemodynamic and Clinical Outcomes.
Zhang B, Salaun E, Côté N, Wu Y, Mahjoub H, Mathieu P, Dahou A, Zenses AS, Clisson M, Pibarot P, Clavel MA.
J Am Coll Cardiol. 2020 Oct 13;76(15):1737-1748. doi: 10.1016/j.jacc.2020.08.034.
PMID: 33032735
Acute and Chronic Impact of Biliopancreatic Diversion with Duodenal Switch Surgery on Plasma Lipoprotein(a) Levels in Patients with Severe Obesity.
Després AA, Piché ME, Auclair A, Biertho L, Marceau S, Hould FS, Biron S, Lebel S, Lescelleur O, Julien F, Martin J, Tchernof A, Mathieu P, Poirier P, Arsenault BJ.Obes Surg. 2020 Oct;30(10):3714-3720. doi: 10.1007/s11695-020-04450-2. Epub 2020 Jul 14.
PMID: 32666413
Interaction of Autotaxin With Lipoprotein(a) in Patients With Calcific Aortic Valve Stenosis.
Bourgeois R, Devillers R, Perrot N, Després AA, Boulanger MC, Mitchell PL, Guertin J, Couture P, Boffa MB, Scipione CA, Pibarot P, Koschinsky ML, Mathieu P, Arsenault BJ.
JACC Basic Transl Sci. 2020 Aug 26;5(9):888-897. doi: 10.1016/j.jacbts.2020.06.012. eCollection 2020 Sep.
PMID: 33015412
Visceral adiposity and liver fat as mediators of the association between cardiorespiratory fitness and plasma glucose-insulin homeostasis.
Chartrand DJ, Larose E, Poirier P, Mathieu P, Alméras N, Pibarot P, Lamarche B, Rhéaume C, Després JP.Am J Physiol Endocrinol Metab. 2020 Sep 1;319(3):E548-E556. doi: 10.1152/ajpendo.00251.2020. Epub 2020 Jul 27.
PMID: 32715747
Lipoprotein-associated phospholipase A2 activity, genetics and calcific aortic valve stenosis in humans.
Perrot N, Thériault S, Rigade S, Chen HY, Dina C, Martinsson A, Boekholdt SM, Capoulade R, Le Tourneau T, Messika-Zeitoun D, Engert JC, Wareham NJ, Clavel MA, Pibarot P, Smith JG, Schott JJ, Mathieu P, Bossé Y, Thanassoulis G, Arsenault BJ.
Heart. 2020 Sep;106(18):1407-1412. doi: 10.1136/heartjnl-2020-316722. Epub 2020 Jul 7.
PMID: 32636298
Phenome-wide analyses establish a specific association between aortic valve PALMD expression and calcific aortic valve stenosis.
Li Z, Gaudreault N, Arsenault BJ, Mathieu P, Bossé Y, Thériault S.
Commun Biol. 2020 Aug 28;3(1):477. doi: 10.1038/s42003-020-01210-x.
PMID: 32859967
Warning AlarmIn Diabetes Mellitus: A Balancing Act Between Inflammation and Redox Signaling in Vascular Mineralization.
Bon-Baret V, Chignon A, Boulanger MC, Mathieu P.
Arterioscler Thromb Vasc Biol. 2020 Aug;40(8):1804-1807. doi: 10.1161/ATVBAHA.120.314733. Epub 2020 Jul 22.
PMID: 32697681
Genetic and In Vitro Inhibition of PCSK9 and Calcific Aortic Valve Stenosis.
Perrot N, Valerio V, Moschetta D, Boekholdt SM, Dina C, Chen HY, Abner E, Martinsson A, Manikpurage HD, Rigade S, Capoulade R, Mass E, Clavel MA, Le Tourneau T, Messika-Zeitoun D, Wareham NJ, Engert JC, Polvani G, Pibarot P, Esko T, Smith JG, Mathieu P, Thanassoulis G, Schott JJ, Bossé Y, Camera M, Thériault S, Poggio P, Arsenault BJ.
JACC Basic Transl Sci. 2020 Jul 1;5(7):649-661. doi: 10.1016/j.jacbts.2020.05.004. eCollection 2020 Jul.
PMID: 32760854
Dietary sucrose induces metabolic inflammation and atherosclerotic cardiovascular diseases more than dietary fat in LDLr-/-ApoB100/100 mice.
Perazza LR, Mitchell PL, Jensen BAH, Daniel N, Boyer M, Varin TV, Bouchareb R, Nachbar RT, Bouchard M, Blais M, Gagné A, Joubert P, Sweeney G, Roy D, Arsenault BJ, Mathieu P, Marette A.
Atherosclerosis. 2020 Jul;304:9-21. doi: 10.1016/j.atherosclerosis.2020.05.002. Epub 2020 May 24.
PMID: 32563005
Association of FADS1/2 Locus Variants and Polyunsaturated Fatty Acids With Aortic Stenosis.
Chen HY, Cairns BJ, Small AM, Burr HA, Ambikkumar A, Martinsson A, Thériault S, Munter HM, Steffen B, Zhang R, Levinson RT, Shaffer CM, Rong J, Sonestedt E, Dufresne L, Ljungberg J, Näslund U, Johansson B, Ranatunga DK, Whitmer RA, Budoff MJ, Nguyen A, Vasan RS, Larson MG, Harris WS, Damrauer SM, Stark KD, Boekholdt SM, Wareham NJ, Pibarot P, Arsenault BJ, Mathieu P, Gudnason V, O'Donnell CJ, Rotter JI, Tsai MY, Post WS, Clarke R, Söderberg S, Bossé Y, Wells QS, Smith JG, Rader DJ, Lathrop M, Engert JC, Thanassoulis G.
JAMA Cardiol. 2020 Mar 18:e200246. doi: 10.1001/jamacardio.2020.0246. Online ahead of print.
PMID: 32186652
Age, Sex, and Valve Phenotype Differences in Fibro-Calcific Remodeling of Calcified Aortic Valve.
Voisine M, Hervault M, Shen M, Boilard AJ, Filion B, Rosa M, Bossé Y, Mathieu P, Côté N, Clavel MA.
J Am Heart Assoc. 2020 May 8:e015610. doi: 10.1161/JAHA.119.015610. Online ahead of print.
MID: 32384012
Single-cell expression and Mendelian randomization analyses identify blood genes associated with lifespan and chronic diseases.
Chignon A, Bon-Baret V, Boulanger MC, Li Z, Argaud D, Bossé Y, Thériault S, Arsenault BJ, Mathieu P.
Commun Biol. 2020 May 1;3(1):206. doi: 10.1038/s42003-020-0937-x
PMID: 32358504
ApoCIII-Lp(a) complexes in conjunction with Lp(a)-OxPL predict rapid progression of aortic stenosis.
Capoulade R, Torzewski M, Mayr M, Chan KL, Mathieu P, Bossé Y, Dumesnil JG, Tam J, Teo KK, Burnap SA, Schmid J, Gobel N, Franke UFW, Sanchez A, Witztum JL, Yang X, Yeang C, Arsenault B, Després JP, Pibarot P, Tsimikas S.
Heart. 2020 May;106(10):738-745. doi: 10.1136/heartjnl-2019-315840. Epub 2020 Feb 13.
PMID: 32054669
Association of Long-term Exposure to Elevated Lipoprotein(a) Levels With Parental Life Span, Chronic Disease-Free Survival, and Mortality Risk: A Mendelian Randomization Analysis.
Arsenault BJ, Pelletier W, Kaiser Y, Perrot N, Couture C, Khaw KT, Wareham NJ, Bossé Y, Pibarot P, Stroes ESG, Mathieu P, Thériault S, Boekholdt SM.
JAMA Netw Open. 2020 Feb 5;3(2):e200129. doi: 10.1001/jamanetworkopen.2020.0129.
PMID: 32108890
Attenuated Mitral Leaflet Enlargement Contributes to Functional Mitral Regurgitation After Myocardial Infarction.
Marsit O, Clavel MA, Côté-Laroche C, Hadjadj S, Bouchard MA, Handschumacher MD, Clisson M, Drolet MC, Boulanger MC, Kim DH, Guerrero JL, Bartko PE, Couet J, Arsenault M, Mathieu P, Pibarot P, Aïkawa E, Bischoff J, Levine RA, Beaudoin J.
J Am Coll Cardiol. 2020 Feb 4;75(4):395-405. doi: 10.1016/j.jacc.2019.11.039.
PMID: 32000951
2019
Genetic Association Analyses Highlight IL6, ALPL, and NAV1 As 3 New Susceptibility Genes Underlying Calcific Aortic Valve Stenosis.
Thériault S, Dina C, Messika-Zeitoun D, Le Scouarnec S, Capoulade R, Gaudreault N, Rigade S, Li Z, Simonet F, Lamontagne M, Clavel MA, Arsenault BJ, Boureau AS, Lecointe S, Baron E, Bonnaud S, Karakachoff M, Charpentier E, Fellah I, Roussel JC, Philippe Verhoye J, Baufreton C, Probst V, Roussel R; D.E.S.I.R. Study Group, Redon R, Dagenais F, Pibarot P, Mathieu P, Le Tourneau T, Bossé Y, Schott JJ.
Circ Genom Precis Med. 2019 Oct;12(10):e002617. doi: 10.1161/CIRCGEN.119.002617. Epub 2019 Oct 15.
PMID: 32141789
A Mendelian randomization study of IL6 signaling in cardiovascular diseases, immune-related disorders and longevity.
Rosa M, Chignon A, Li Z, Boulanger MC, Arsenault BJ, Bossé Y, Thériault S, Mathieu P.
NPJ Genom Med. 2019 Sep 20;4:23. doi: 10.1038/s41525-019-0097-4. eCollection 2019.
PMID: 31552141
Enhancer-mediated enrichment of interacting JMJD3-DDX21 to ENPP2 locus prevents R-loop formation and promotes transcription.
Argaud D, Boulanger MC, Chignon A, Mkannez G, Mathieu P.
Nucleic Acids Res. 2019 Jun 28. pii: gkz560. doi: 10.1093/nar/gkz560. [Epub ahead of print]
PMID:31251802
Genetic Variation in LPA, Calcific Aortic Valve Stenosis in Patients Undergoing Cardiac Surgery, and Familial Risk of Aortic Valve Microcalcification.
Perrot N, Thériault S, Dina C, Chen HY, Boekholdt SM, Rigade S, Després AA, Poulin A, Capoulade R, Le Tourneau T, Messika-Zeitoun D, Trottier M, Tessier M, Guimond J, Nadeau M, Engert JC, Khaw KT, Wareham NJ, Dweck MR, Mathieu P, Pibarot P, Schott JJ, Thanassoulis G, Clavel MA, Bossé Y, Arsenault BJ.
JAMA Cardiol. 2019 Jul 1;4(7):620-627. doi: 10.1001/jamacardio.2019.1581.
PMID: 31141105
Lipoprotein(a), Oxidized Phospholipids, and Aortic Valve Microcalcification Assessed by 18F-Sodium Fluoride Positron Emission Tomography and Computed Tomography.
Després AA, Perrot N, Poulin A, Tastet L, Shen M, Chen HY, Bourgeois R, Trottier M, Tessier M, Guimond J, Nadeau M, Engert JC, Thériault S, Bossé Y, Witztum JL, Couture P, Mathieu P, Dweck MR, Tsimikas S, Thanassoulis G, Pibarot P, Clavel MA, Arsenault BJ.
CJC Open. 2019 Apr 12;1(3):131-140. doi: 10.1016/j.cjco.2019.03.004. eCollection 2019 May.
PMID: 32159096
Activated platelets promote an osteogenic programme and the progression of calcific aortic valve stenosis.
Bouchareb R, Boulanger MC, Tastet L, Mkannez G, Nsaibia MJ, Hadji F, Dahou A, Messadeq Y, Arsenault BJ, Pibarot P, Bossé Y, Marette A, Mathieu P.
Eur Heart J. 2019 May 1;40(17):1362-1373. doi: 10.1093/eurheartj/ehy696.
PMID:30395215
UCP1 expression-associated gene signatures of human epicardial adipose tissue.
Chechi K, Vijay J, Voisine P, Mathieu P, Bossé Y, Tchernof A, Grundberg E, Richard D.
JCI Insight. 2019 Apr 18;4(8):e123618. doi: 10.1172/jci.insight.123618. eCollection 2019 Apr 18.
PMID: 30996144
Benefits of 1-Year Lifestyle Modification Program on Exercise Capacity and Diastolic Function Among Coronary Artery Disease Men With and Without Type 2 Diabetes.
Piché ME, Poirier P, Marette A, Mathieu P, Lévesque V, Bibeau K, Larose É, Després JP.
Metab Syndr Relat Disord. 2019 Apr;17(3):149-159. doi: 10.1089/met.2018.0092. Epub 2019 Feb 21.
PMID: 30789304
PALMD as a novel target for calcific aortic valve stenosis (REVIEW)
Bossé Y, Mathieu P, Thériault S.
Curr Opin Cardiol. 2019 Mar;34(2):105-111. doi: 10.1097/HCO.0000000000000605.
PMID:30608251
Acute and chronic effect of bariatric surgery on circulating autotaxin levels.
Bourgeois R, Piché ME, Auclair A, Grenier-Larouche T, Mitchell PL, Poirier P, Biertho L, Marceau S, Hould FS, Biron S, Lebel S, Lescelleur O, Julien F, Martin J, Tchernof A, Mathieu P, Carpentier AC, Arsenault BJ.
Physiol Rep. 2019 Mar;7(5):e14004. doi: 10.14814/phy2.14004.
PMID: 30821134
Autotaxin and Lipoprotein Metabolism in Calcific Aortic Valve Disease. (REVIEW)
Mathieu P, Boulanger MC.
Front Cardiovasc Med. 2019 Mar 1;6:18. doi: 10.3389/fcvm.2019.00018. eCollection 2019. Review.
PMID:30881959
Review articles
Before 2019
Pathobiology of Lp(a) in calcific aortic valve disease. (REVIEW)
Mathieu P, Arsenault BJ, Boulanger MC, Bossé Y, Koschinsky ML.
Expert Rev Cardiovasc Ther. 2017 Oct;15(10):797-807. doi: 10.1080/14779072.2017.1367286. Epub 2017 Aug 24. Review.
PMID:28816078
CAVD: civilization aortic valve disease. (REVIEW)
Mathieu P, Arsenault BJ.
Eur Heart J. 2017 Jul 21;38(28):2198-2200. doi: 10.1093/eurheartj/ehx219. No abstract available.
PMID:28453620
Calcific aortic stenosis. (REVIEW)
Lindman BR, Clavel MA, Mathieu P, Iung B, Lancellotti P, Otto CM, Pibarot P.
Nat Rev Dis Primers. 2016 Mar 3;2:16006. doi: 10.1038/nrdp.2016.6. Review.
PMID: 27188578
Mathieu P, Arsenault BJ, Boulanger MC, Bossé Y, Koschinsky ML.
Expert Rev Cardiovasc Ther. 2017 Oct;15(10):797-807. doi: 10.1080/14779072.2017.1367286. Epub 2017 Aug 24. Review.
PMID:28816078
CAVD: civilization aortic valve disease. (REVIEW)
Mathieu P, Arsenault BJ.
Eur Heart J. 2017 Jul 21;38(28):2198-2200. doi: 10.1093/eurheartj/ehx219. No abstract available.
PMID:28453620
Calcific aortic stenosis. (REVIEW)
Lindman BR, Clavel MA, Mathieu P, Iung B, Lancellotti P, Otto CM, Pibarot P.
Nat Rev Dis Primers. 2016 Mar 3;2:16006. doi: 10.1038/nrdp.2016.6. Review.
PMID: 27188578