Research articles
A Mendelian randomization study of IL6 signaling in cardiovascular diseases, immune-related disorders and longevity.
Rosa M, Chignon A, Li Z, Boulanger MC, Arsenault BJ, Bossé Y, Thériault S, Mathieu P.
NPJ Genom Med. 2019 Sep 20;4:23. doi: 10.1038/s41525-019-0097-4. eCollection 2019.
PMID: 31552141
Enhancer-mediated enrichment of interacting JMJD3-DDX21 to ENPP2 locus prevents R-loop formation and promotes transcription.
Argaud D, Boulanger MC, Chignon A, Mkannez G, Mathieu P.
Nucleic Acids Res. 2019 Jun 28. pii: gkz560. doi: 10.1093/nar/gkz560. [Epub ahead of print]
PMID:31251802
Activated platelets promote an osteogenic programme and the progression of calcific aortic valve stenosis.
Bouchareb R, Boulanger MC, Tastet L, Mkannez G, Nsaibia MJ, Hadji F, Dahou A, Messadeq Y, Arsenault BJ, Pibarot P, Bossé Y, Marette A, Mathieu P.
Eur Heart J. 2019 May 1;40(17):1362-1373. doi: 10.1093/eurheartj/ehy696.
PMID:30395215
DNA methylation of a PLPP3 MIR transposon-based enhancer promotes an osteogenic programme in calcific aortic valve disease.
Mkannez G, Gagné-Ouellet V, Jalloul Nsaibia M, Boulanger MC, Rosa M, Argaud D, Hadji F, Gaudreault N, Rhéaume G, Bouchard L, Bossé Y, Mathieu P.
Cardiovasc Res. 2018 Sep 1;114(11):1525-1535. doi: 10.1093/cvr/cvy111.
PMID:29726894
A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis.
Thériault S, Gaudreault N, Lamontagne M, Rosa M, Boulanger MC, Messika-Zeitoun D, Clavel MA, Capoulade R, Dagenais F, Pibarot P, Mathieu P, Bossé Y.
Nat Commun. 2018 Mar 7;9(1):988. doi: 10.1038/s41467-018-03260-6.
PMID: 29511167
Coronary Artery Disease Affects Symptomatology of Aortic Valve Stenosis.
Boekholdt SM, Arsenault BJ, Mathieu P.
J Am Coll Cardiol. 2017 Aug 22;70(8):1103-1104. doi: 10.1016/j.jacc.2017.04.072. No abstract available.
PMID:28818194
OxLDL-derived lysophosphatidic acid promotes the progression of aortic valve stenosis through a LPAR1-RhoA-NF-κB pathway.
Nsaibia MJ, Boulanger MC, Bouchareb R, Mkannez G, Le Quang K, Hadji F, Argaud D, Dahou A, Bossé Y, Koschinsky ML, Pibarot P, Arsenault BJ, Marette A, Mathieu P.
Cardiovasc Res. 2017 Sep 1;113(11):1351-1363. doi: 10.1093/cvr/cvx089.
PMID:28472283
Altered DNA Methylation of Long Noncoding RNA H19 in Calcific Aortic Valve Disease Promotes Mineralization by Silencing NOTCH1.
Hadji F, Boulanger MC, Guay SP, Gaudreault N, Amellah S, Mkannez G, Bouchareb R, Marchand JT, Nsaibia MJ, Guauque-Olarte S, Pibarot P, Bouchard L, Bossé Y, Mathieu P.
Circulation. 2016 Dec 6;134(23):1848-1862. Epub 2016 Oct 27.
PMID:27789555
Autotaxin interacts with lipoprotein(a) and oxidized phospholipids in predicting the risk of calcific aortic valve stenosis in patients with coronary artery disease.
Nsaibia MJ, Mahmut A, Boulanger MC, Arsenault BJ, Bouchareb R, Simard S, Witztum JL, Clavel MA, Pibarot P, Bossé Y, Tsimikas S, Mathieu P.
J Intern Med. 2016 Nov;280(5):509-517. doi: 10.1111/joim.12519. Epub 2016 May 30.
PMID:27237700
Autotaxin Derived From Lipoprotein(a) and Valve Interstitial Cells Promotes Inflammation and Mineralization of the Aortic Valve.
Bouchareb R, Mahmut A, Nsaibia MJ, Boulanger MC, Dahou A, Lépine JL, Laflamme MH, Hadji F, Couture C, Trahan S, Pagé S, Bossé Y, Pibarot P, Scipione CA, Romagnuolo R, Koschinsky ML, Arsenault BJ, Marette A, Mathieu P.
Circulation. 2015 Aug 25;132(8):677-90. doi: 10.1161/CIRCULATIONAHA.115.016757. Epub 2015 Jul 29.
PMID:26224810
Rosa M, Chignon A, Li Z, Boulanger MC, Arsenault BJ, Bossé Y, Thériault S, Mathieu P.
NPJ Genom Med. 2019 Sep 20;4:23. doi: 10.1038/s41525-019-0097-4. eCollection 2019.
PMID: 31552141
Enhancer-mediated enrichment of interacting JMJD3-DDX21 to ENPP2 locus prevents R-loop formation and promotes transcription.
Argaud D, Boulanger MC, Chignon A, Mkannez G, Mathieu P.
Nucleic Acids Res. 2019 Jun 28. pii: gkz560. doi: 10.1093/nar/gkz560. [Epub ahead of print]
PMID:31251802
Activated platelets promote an osteogenic programme and the progression of calcific aortic valve stenosis.
Bouchareb R, Boulanger MC, Tastet L, Mkannez G, Nsaibia MJ, Hadji F, Dahou A, Messadeq Y, Arsenault BJ, Pibarot P, Bossé Y, Marette A, Mathieu P.
Eur Heart J. 2019 May 1;40(17):1362-1373. doi: 10.1093/eurheartj/ehy696.
PMID:30395215
DNA methylation of a PLPP3 MIR transposon-based enhancer promotes an osteogenic programme in calcific aortic valve disease.
Mkannez G, Gagné-Ouellet V, Jalloul Nsaibia M, Boulanger MC, Rosa M, Argaud D, Hadji F, Gaudreault N, Rhéaume G, Bouchard L, Bossé Y, Mathieu P.
Cardiovasc Res. 2018 Sep 1;114(11):1525-1535. doi: 10.1093/cvr/cvy111.
PMID:29726894
A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis.
Thériault S, Gaudreault N, Lamontagne M, Rosa M, Boulanger MC, Messika-Zeitoun D, Clavel MA, Capoulade R, Dagenais F, Pibarot P, Mathieu P, Bossé Y.
Nat Commun. 2018 Mar 7;9(1):988. doi: 10.1038/s41467-018-03260-6.
PMID: 29511167
Coronary Artery Disease Affects Symptomatology of Aortic Valve Stenosis.
Boekholdt SM, Arsenault BJ, Mathieu P.
J Am Coll Cardiol. 2017 Aug 22;70(8):1103-1104. doi: 10.1016/j.jacc.2017.04.072. No abstract available.
PMID:28818194
OxLDL-derived lysophosphatidic acid promotes the progression of aortic valve stenosis through a LPAR1-RhoA-NF-κB pathway.
Nsaibia MJ, Boulanger MC, Bouchareb R, Mkannez G, Le Quang K, Hadji F, Argaud D, Dahou A, Bossé Y, Koschinsky ML, Pibarot P, Arsenault BJ, Marette A, Mathieu P.
Cardiovasc Res. 2017 Sep 1;113(11):1351-1363. doi: 10.1093/cvr/cvx089.
PMID:28472283
Altered DNA Methylation of Long Noncoding RNA H19 in Calcific Aortic Valve Disease Promotes Mineralization by Silencing NOTCH1.
Hadji F, Boulanger MC, Guay SP, Gaudreault N, Amellah S, Mkannez G, Bouchareb R, Marchand JT, Nsaibia MJ, Guauque-Olarte S, Pibarot P, Bouchard L, Bossé Y, Mathieu P.
Circulation. 2016 Dec 6;134(23):1848-1862. Epub 2016 Oct 27.
PMID:27789555
Autotaxin interacts with lipoprotein(a) and oxidized phospholipids in predicting the risk of calcific aortic valve stenosis in patients with coronary artery disease.
Nsaibia MJ, Mahmut A, Boulanger MC, Arsenault BJ, Bouchareb R, Simard S, Witztum JL, Clavel MA, Pibarot P, Bossé Y, Tsimikas S, Mathieu P.
J Intern Med. 2016 Nov;280(5):509-517. doi: 10.1111/joim.12519. Epub 2016 May 30.
PMID:27237700
Autotaxin Derived From Lipoprotein(a) and Valve Interstitial Cells Promotes Inflammation and Mineralization of the Aortic Valve.
Bouchareb R, Mahmut A, Nsaibia MJ, Boulanger MC, Dahou A, Lépine JL, Laflamme MH, Hadji F, Couture C, Trahan S, Pagé S, Bossé Y, Pibarot P, Scipione CA, Romagnuolo R, Koschinsky ML, Arsenault BJ, Marette A, Mathieu P.
Circulation. 2015 Aug 25;132(8):677-90. doi: 10.1161/CIRCULATIONAHA.115.016757. Epub 2015 Jul 29.
PMID:26224810
Review articles
Autotaxin and Lipoprotein Metabolism in Calcific Aortic Valve Disease.
Mathieu P, Boulanger MC.
Front Cardiovasc Med. 2019 Mar 1;6:18. doi: 10.3389/fcvm.2019.00018. eCollection 2019. Review.
PMID:30881959
PALMD as a novel target for calcific aortic valve stenosis.
Bossé Y, Mathieu P, Thériault S.
Curr Opin Cardiol. 2019 Mar;34(2):105-111. doi: 10.1097/HCO.0000000000000605.
PMID:30608251
Pathobiology of Lp(a) in calcific aortic valve disease.
Mathieu P, Arsenault BJ, Boulanger MC, Bossé Y, Koschinsky ML.
Expert Rev Cardiovasc Ther. 2017 Oct;15(10):797-807. doi: 10.1080/14779072.2017.1367286. Epub 2017 Aug 24. Review.
PMID:28816078
CAVD: civilization aortic valve disease.
Mathieu P, Arsenault BJ.
Eur Heart J. 2017 Jul 21;38(28):2198-2200. doi: 10.1093/eurheartj/ehx219. No abstract available.
PMID:28453620
Calcific aortic stenosis.
Lindman BR, Clavel MA, Mathieu P, Iung B, Lancellotti P, Otto CM, Pibarot P.
Nat Rev Dis Primers. 2016 Mar 3;2:16006. doi: 10.1038/nrdp.2016.6. Review.
PMID: 27188578
Mathieu P, Boulanger MC.
Front Cardiovasc Med. 2019 Mar 1;6:18. doi: 10.3389/fcvm.2019.00018. eCollection 2019. Review.
PMID:30881959
PALMD as a novel target for calcific aortic valve stenosis.
Bossé Y, Mathieu P, Thériault S.
Curr Opin Cardiol. 2019 Mar;34(2):105-111. doi: 10.1097/HCO.0000000000000605.
PMID:30608251
Pathobiology of Lp(a) in calcific aortic valve disease.
Mathieu P, Arsenault BJ, Boulanger MC, Bossé Y, Koschinsky ML.
Expert Rev Cardiovasc Ther. 2017 Oct;15(10):797-807. doi: 10.1080/14779072.2017.1367286. Epub 2017 Aug 24. Review.
PMID:28816078
CAVD: civilization aortic valve disease.
Mathieu P, Arsenault BJ.
Eur Heart J. 2017 Jul 21;38(28):2198-2200. doi: 10.1093/eurheartj/ehx219. No abstract available.
PMID:28453620
Calcific aortic stenosis.
Lindman BR, Clavel MA, Mathieu P, Iung B, Lancellotti P, Otto CM, Pibarot P.
Nat Rev Dis Primers. 2016 Mar 3;2:16006. doi: 10.1038/nrdp.2016.6. Review.
PMID: 27188578