Research articles
2020
Single-cell expression and Mendelian randomization analyses identify blood genes associated with lifespan and chronic diseases.
Chignon A, Bon-Baret V, Boulanger MC, Li Z, Argaud D, Bossé Y, Thériault S, Arsenault BJ, Mathieu P.
Commun Biol. 2020 May 1;3(1):206. doi: 10.1038/s42003-020-0937-x
PMID: 32358504
ApoCIII-Lp(a) complexes in conjunction with Lp(a)-OxPL predict rapid progression of aortic stenosis.
Capoulade R, Torzewski M, Mayr M, Chan KL, Mathieu P, Bossé Y, Dumesnil JG, Tam J, Teo KK, Burnap SA, Schmid J, Gobel N, Franke UFW, Sanchez A, Witztum JL, Yang X, Yeang C, Arsenault B, Després JP, Pibarot P, Tsimikas S.
Heart. 2020 May;106(10):738-745. doi: 10.1136/heartjnl-2019-315840. Epub 2020 Feb 13.
PMID: 32054669
Age, Sex, and Valve Phenotype Differences in Fibro-Calcific Remodeling of Calcified Aortic Valve.
Voisine M, Hervault M, Shen M, Boilard AJ, Filion B, Rosa M, Bossé Y, Mathieu P, Côté N, Clavel MA.
J Am Heart Assoc. 2020 May 8:e015610. doi: 10.1161/JAHA.119.015610. Online ahead of print.
MID: 32384012
Association of FADS1/2 Locus Variants and Polyunsaturated Fatty Acids With Aortic Stenosis.
Chen HY, Cairns BJ, Small AM, Burr HA, Ambikkumar A, Martinsson A, Thériault S, Munter HM, Steffen B, Zhang R, Levinson RT, Shaffer CM, Rong J, Sonestedt E, Dufresne L, Ljungberg J, Näslund U, Johansson B, Ranatunga DK, Whitmer RA, Budoff MJ, Nguyen A, Vasan RS, Larson MG, Harris WS, Damrauer SM, Stark KD, Boekholdt SM, Wareham NJ, Pibarot P, Arsenault BJ, Mathieu P, Gudnason V, O'Donnell CJ, Rotter JI, Tsai MY, Post WS, Clarke R, Söderberg S, Bossé Y, Wells QS, Smith JG, Rader DJ, Lathrop M, Engert JC, Thanassoulis G.
JAMA Cardiol. 2020 Mar 18:e200246. doi: 10.1001/jamacardio.2020.0246. Online ahead of print.
PMID: 32186652
Association of Long-term Exposure to Elevated Lipoprotein(a) Levels With Parental Life Span, Chronic Disease-Free Survival, and Mortality Risk: A Mendelian Randomization Analysis.
Arsenault BJ, Pelletier W, Kaiser Y, Perrot N, Couture C, Khaw KT, Wareham NJ, Bossé Y, Pibarot P, Stroes ESG, Mathieu P, Thériault S, Boekholdt SM.
JAMA Netw Open. 2020 Feb 5;3(2):e200129. doi: 10.1001/jamanetworkopen.2020.0129.
PMID: 32108890
Attenuated Mitral Leaflet Enlargement Contributes to Functional Mitral Regurgitation After Myocardial Infarction.
Marsit O, Clavel MA, Côté-Laroche C, Hadjadj S, Bouchard MA, Handschumacher MD, Clisson M, Drolet MC, Boulanger MC, Kim DH, Guerrero JL, Bartko PE, Couet J, Arsenault M, Mathieu P, Pibarot P, Aïkawa E, Bischoff J, Levine RA, Beaudoin J.
J Am Coll Cardiol. 2020 Feb 4;75(4):395-405. doi: 10.1016/j.jacc.2019.11.039.
PMID: 32000951
2019
Genetic Association Analyses Highlight IL6, ALPL, and NAV1 As 3 New Susceptibility Genes Underlying Calcific Aortic Valve Stenosis.
Thériault S, Dina C, Messika-Zeitoun D, Le Scouarnec S, Capoulade R, Gaudreault N, Rigade S, Li Z, Simonet F, Lamontagne M, Clavel MA, Arsenault BJ, Boureau AS, Lecointe S, Baron E, Bonnaud S, Karakachoff M, Charpentier E, Fellah I, Roussel JC, Philippe Verhoye J, Baufreton C, Probst V, Roussel R; D.E.S.I.R. Study Group, Redon R, Dagenais F, Pibarot P, Mathieu P, Le Tourneau T, Bossé Y, Schott JJ.
Circ Genom Precis Med. 2019 Oct;12(10):e002617. doi: 10.1161/CIRCGEN.119.002617. Epub 2019 Oct 15.
PMID: 32141789
A Mendelian randomization study of IL6 signaling in cardiovascular diseases, immune-related disorders and longevity.
Rosa M, Chignon A, Li Z, Boulanger MC, Arsenault BJ, Bossé Y, Thériault S, Mathieu P.
NPJ Genom Med. 2019 Sep 20;4:23. doi: 10.1038/s41525-019-0097-4. eCollection 2019.
PMID: 31552141
Genetic Variation in LPA, Calcific Aortic Valve Stenosis in Patients Undergoing Cardiac Surgery, and Familial Risk of Aortic Valve Microcalcification.
Perrot N, Thériault S, Dina C, Chen HY, Boekholdt SM, Rigade S, Després AA, Poulin A, Capoulade R, Le Tourneau T, Messika-Zeitoun D, Trottier M, Tessier M, Guimond J, Nadeau M, Engert JC, Khaw KT, Wareham NJ, Dweck MR, Mathieu P, Pibarot P, Schott JJ, Thanassoulis G, Clavel MA, Bossé Y, Arsenault BJ.
JAMA Cardiol. 2019 Jul 1;4(7):620-627. doi: 10.1001/jamacardio.2019.1581.
PMID: 31141105
Enhancer-mediated enrichment of interacting JMJD3-DDX21 to ENPP2 locus prevents R-loop formation and promotes transcription.
Argaud D, Boulanger MC, Chignon A, Mkannez G, Mathieu P.
Nucleic Acids Res. 2019 Jun 28. pii: gkz560. doi: 10.1093/nar/gkz560. [Epub ahead of print]
PMID:31251802
Activated platelets promote an osteogenic programme and the progression of calcific aortic valve stenosis.
Bouchareb R, Boulanger MC, Tastet L, Mkannez G, Nsaibia MJ, Hadji F, Dahou A, Messadeq Y, Arsenault BJ, Pibarot P, Bossé Y, Marette A, Mathieu P.
Eur Heart J. 2019 May 1;40(17):1362-1373. doi: 10.1093/eurheartj/ehy696.
PMID:30395215
Benefits of 1-Year Lifestyle Modification Program on Exercise Capacity and Diastolic Function Among Coronary Artery Disease Men With and Without Type 2 Diabetes.
Piché ME, Poirier P, Marette A, Mathieu P, Lévesque V, Bibeau K, Larose É, Després JP.
Metab Syndr Relat Disord. 2019 Apr;17(3):149-159. doi: 10.1089/met.2018.0092. Epub 2019 Feb 21.
PMID: 30789304
Lipoprotein(a), Oxidized Phospholipids, and Aortic Valve Microcalcification Assessed by 18F-Sodium Fluoride Positron Emission Tomography and Computed Tomography.
Després AA, Perrot N, Poulin A, Tastet L, Shen M, Chen HY, Bourgeois R, Trottier M, Tessier M, Guimond J, Nadeau M, Engert JC, Thériault S, Bossé Y, Witztum JL, Couture P, Mathieu P, Dweck MR, Tsimikas S, Thanassoulis G, Pibarot P, Clavel MA, Arsenault BJ.
CJC Open. 2019 Apr 12;1(3):131-140. doi: 10.1016/j.cjco.2019.03.004. eCollection 2019 May.
PMID: 32159096
Acute and chronic effect of bariatric surgery on circulating autotaxin levels.
Bourgeois R, Piché ME, Auclair A, Grenier-Larouche T, Mitchell PL, Poirier P, Biertho L, Marceau S, Hould FS, Biron S, Lebel S, Lescelleur O, Julien F, Martin J, Tchernof A, Mathieu P, Carpentier AC, Arsenault BJ.
Physiol Rep. 2019 Mar;7(5):e14004. doi: 10.14814/phy2.14004.
PMID: 30821134
Single-cell expression and Mendelian randomization analyses identify blood genes associated with lifespan and chronic diseases.
Chignon A, Bon-Baret V, Boulanger MC, Li Z, Argaud D, Bossé Y, Thériault S, Arsenault BJ, Mathieu P.
Commun Biol. 2020 May 1;3(1):206. doi: 10.1038/s42003-020-0937-x
PMID: 32358504
ApoCIII-Lp(a) complexes in conjunction with Lp(a)-OxPL predict rapid progression of aortic stenosis.
Capoulade R, Torzewski M, Mayr M, Chan KL, Mathieu P, Bossé Y, Dumesnil JG, Tam J, Teo KK, Burnap SA, Schmid J, Gobel N, Franke UFW, Sanchez A, Witztum JL, Yang X, Yeang C, Arsenault B, Després JP, Pibarot P, Tsimikas S.
Heart. 2020 May;106(10):738-745. doi: 10.1136/heartjnl-2019-315840. Epub 2020 Feb 13.
PMID: 32054669
Age, Sex, and Valve Phenotype Differences in Fibro-Calcific Remodeling of Calcified Aortic Valve.
Voisine M, Hervault M, Shen M, Boilard AJ, Filion B, Rosa M, Bossé Y, Mathieu P, Côté N, Clavel MA.
J Am Heart Assoc. 2020 May 8:e015610. doi: 10.1161/JAHA.119.015610. Online ahead of print.
MID: 32384012
Association of FADS1/2 Locus Variants and Polyunsaturated Fatty Acids With Aortic Stenosis.
Chen HY, Cairns BJ, Small AM, Burr HA, Ambikkumar A, Martinsson A, Thériault S, Munter HM, Steffen B, Zhang R, Levinson RT, Shaffer CM, Rong J, Sonestedt E, Dufresne L, Ljungberg J, Näslund U, Johansson B, Ranatunga DK, Whitmer RA, Budoff MJ, Nguyen A, Vasan RS, Larson MG, Harris WS, Damrauer SM, Stark KD, Boekholdt SM, Wareham NJ, Pibarot P, Arsenault BJ, Mathieu P, Gudnason V, O'Donnell CJ, Rotter JI, Tsai MY, Post WS, Clarke R, Söderberg S, Bossé Y, Wells QS, Smith JG, Rader DJ, Lathrop M, Engert JC, Thanassoulis G.
JAMA Cardiol. 2020 Mar 18:e200246. doi: 10.1001/jamacardio.2020.0246. Online ahead of print.
PMID: 32186652
Association of Long-term Exposure to Elevated Lipoprotein(a) Levels With Parental Life Span, Chronic Disease-Free Survival, and Mortality Risk: A Mendelian Randomization Analysis.
Arsenault BJ, Pelletier W, Kaiser Y, Perrot N, Couture C, Khaw KT, Wareham NJ, Bossé Y, Pibarot P, Stroes ESG, Mathieu P, Thériault S, Boekholdt SM.
JAMA Netw Open. 2020 Feb 5;3(2):e200129. doi: 10.1001/jamanetworkopen.2020.0129.
PMID: 32108890
Attenuated Mitral Leaflet Enlargement Contributes to Functional Mitral Regurgitation After Myocardial Infarction.
Marsit O, Clavel MA, Côté-Laroche C, Hadjadj S, Bouchard MA, Handschumacher MD, Clisson M, Drolet MC, Boulanger MC, Kim DH, Guerrero JL, Bartko PE, Couet J, Arsenault M, Mathieu P, Pibarot P, Aïkawa E, Bischoff J, Levine RA, Beaudoin J.
J Am Coll Cardiol. 2020 Feb 4;75(4):395-405. doi: 10.1016/j.jacc.2019.11.039.
PMID: 32000951
2019
Genetic Association Analyses Highlight IL6, ALPL, and NAV1 As 3 New Susceptibility Genes Underlying Calcific Aortic Valve Stenosis.
Thériault S, Dina C, Messika-Zeitoun D, Le Scouarnec S, Capoulade R, Gaudreault N, Rigade S, Li Z, Simonet F, Lamontagne M, Clavel MA, Arsenault BJ, Boureau AS, Lecointe S, Baron E, Bonnaud S, Karakachoff M, Charpentier E, Fellah I, Roussel JC, Philippe Verhoye J, Baufreton C, Probst V, Roussel R; D.E.S.I.R. Study Group, Redon R, Dagenais F, Pibarot P, Mathieu P, Le Tourneau T, Bossé Y, Schott JJ.
Circ Genom Precis Med. 2019 Oct;12(10):e002617. doi: 10.1161/CIRCGEN.119.002617. Epub 2019 Oct 15.
PMID: 32141789
A Mendelian randomization study of IL6 signaling in cardiovascular diseases, immune-related disorders and longevity.
Rosa M, Chignon A, Li Z, Boulanger MC, Arsenault BJ, Bossé Y, Thériault S, Mathieu P.
NPJ Genom Med. 2019 Sep 20;4:23. doi: 10.1038/s41525-019-0097-4. eCollection 2019.
PMID: 31552141
Genetic Variation in LPA, Calcific Aortic Valve Stenosis in Patients Undergoing Cardiac Surgery, and Familial Risk of Aortic Valve Microcalcification.
Perrot N, Thériault S, Dina C, Chen HY, Boekholdt SM, Rigade S, Després AA, Poulin A, Capoulade R, Le Tourneau T, Messika-Zeitoun D, Trottier M, Tessier M, Guimond J, Nadeau M, Engert JC, Khaw KT, Wareham NJ, Dweck MR, Mathieu P, Pibarot P, Schott JJ, Thanassoulis G, Clavel MA, Bossé Y, Arsenault BJ.
JAMA Cardiol. 2019 Jul 1;4(7):620-627. doi: 10.1001/jamacardio.2019.1581.
PMID: 31141105
Enhancer-mediated enrichment of interacting JMJD3-DDX21 to ENPP2 locus prevents R-loop formation and promotes transcription.
Argaud D, Boulanger MC, Chignon A, Mkannez G, Mathieu P.
Nucleic Acids Res. 2019 Jun 28. pii: gkz560. doi: 10.1093/nar/gkz560. [Epub ahead of print]
PMID:31251802
Activated platelets promote an osteogenic programme and the progression of calcific aortic valve stenosis.
Bouchareb R, Boulanger MC, Tastet L, Mkannez G, Nsaibia MJ, Hadji F, Dahou A, Messadeq Y, Arsenault BJ, Pibarot P, Bossé Y, Marette A, Mathieu P.
Eur Heart J. 2019 May 1;40(17):1362-1373. doi: 10.1093/eurheartj/ehy696.
PMID:30395215
Benefits of 1-Year Lifestyle Modification Program on Exercise Capacity and Diastolic Function Among Coronary Artery Disease Men With and Without Type 2 Diabetes.
Piché ME, Poirier P, Marette A, Mathieu P, Lévesque V, Bibeau K, Larose É, Després JP.
Metab Syndr Relat Disord. 2019 Apr;17(3):149-159. doi: 10.1089/met.2018.0092. Epub 2019 Feb 21.
PMID: 30789304
Lipoprotein(a), Oxidized Phospholipids, and Aortic Valve Microcalcification Assessed by 18F-Sodium Fluoride Positron Emission Tomography and Computed Tomography.
Després AA, Perrot N, Poulin A, Tastet L, Shen M, Chen HY, Bourgeois R, Trottier M, Tessier M, Guimond J, Nadeau M, Engert JC, Thériault S, Bossé Y, Witztum JL, Couture P, Mathieu P, Dweck MR, Tsimikas S, Thanassoulis G, Pibarot P, Clavel MA, Arsenault BJ.
CJC Open. 2019 Apr 12;1(3):131-140. doi: 10.1016/j.cjco.2019.03.004. eCollection 2019 May.
PMID: 32159096
Acute and chronic effect of bariatric surgery on circulating autotaxin levels.
Bourgeois R, Piché ME, Auclair A, Grenier-Larouche T, Mitchell PL, Poirier P, Biertho L, Marceau S, Hould FS, Biron S, Lebel S, Lescelleur O, Julien F, Martin J, Tchernof A, Mathieu P, Carpentier AC, Arsenault BJ.
Physiol Rep. 2019 Mar;7(5):e14004. doi: 10.14814/phy2.14004.
PMID: 30821134
Review articles
Autotaxin and Lipoprotein Metabolism in Calcific Aortic Valve Disease.
Mathieu P, Boulanger MC.
Front Cardiovasc Med. 2019 Mar 1;6:18. doi: 10.3389/fcvm.2019.00018. eCollection 2019. Review.
PMID:30881959
PALMD as a novel target for calcific aortic valve stenosis.
Bossé Y, Mathieu P, Thériault S.
Curr Opin Cardiol. 2019 Mar;34(2):105-111. doi: 10.1097/HCO.0000000000000605.
PMID:30608251
Pathobiology of Lp(a) in calcific aortic valve disease.
Mathieu P, Arsenault BJ, Boulanger MC, Bossé Y, Koschinsky ML.
Expert Rev Cardiovasc Ther. 2017 Oct;15(10):797-807. doi: 10.1080/14779072.2017.1367286. Epub 2017 Aug 24. Review.
PMID:28816078
CAVD: civilization aortic valve disease.
Mathieu P, Arsenault BJ.
Eur Heart J. 2017 Jul 21;38(28):2198-2200. doi: 10.1093/eurheartj/ehx219. No abstract available.
PMID:28453620
Calcific aortic stenosis.
Lindman BR, Clavel MA, Mathieu P, Iung B, Lancellotti P, Otto CM, Pibarot P.
Nat Rev Dis Primers. 2016 Mar 3;2:16006. doi: 10.1038/nrdp.2016.6. Review.
PMID: 27188578
Mathieu P, Boulanger MC.
Front Cardiovasc Med. 2019 Mar 1;6:18. doi: 10.3389/fcvm.2019.00018. eCollection 2019. Review.
PMID:30881959
PALMD as a novel target for calcific aortic valve stenosis.
Bossé Y, Mathieu P, Thériault S.
Curr Opin Cardiol. 2019 Mar;34(2):105-111. doi: 10.1097/HCO.0000000000000605.
PMID:30608251
Pathobiology of Lp(a) in calcific aortic valve disease.
Mathieu P, Arsenault BJ, Boulanger MC, Bossé Y, Koschinsky ML.
Expert Rev Cardiovasc Ther. 2017 Oct;15(10):797-807. doi: 10.1080/14779072.2017.1367286. Epub 2017 Aug 24. Review.
PMID:28816078
CAVD: civilization aortic valve disease.
Mathieu P, Arsenault BJ.
Eur Heart J. 2017 Jul 21;38(28):2198-2200. doi: 10.1093/eurheartj/ehx219. No abstract available.
PMID:28453620
Calcific aortic stenosis.
Lindman BR, Clavel MA, Mathieu P, Iung B, Lancellotti P, Otto CM, Pibarot P.
Nat Rev Dis Primers. 2016 Mar 3;2:16006. doi: 10.1038/nrdp.2016.6. Review.
PMID: 27188578